%0 Journal Article %T Assessment of Ultrasound / Radio-guided Occult Lesion Localization in Non-palpable Breast Lesions %J Asia Oceania Journal of Nuclear Medicine and Biology %I Mashhad University of Medical Sciences in collaboration with AOFNMB %Z 2322-5718 %A Alamdaran, Seyed Ali %A Sharifi Haddad, Ayda %A Daghighi, Navid %A Modoodi, Elaheh %A Sadeghi, Ramin %A Forghani, Mohammad Naser %A Fattahi, Asieh Sadat %D 2018 %\ 01/01/2018 %V 6 %N 1 %P 10-14 %! Assessment of Ultrasound / Radio-guided Occult Lesion Localization in Non-palpable Breast Lesions %K Non-palpable breast lesion %K localization %K Radiopharmaceuticals %K ROLL %K Ultrasound %R 10.22038/aojnmb.2017.9898 %X Objective(s): Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasoundand radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals. One to ten hours prior to surgery, 0.1-0.2 ml (equivalent to 0.5-1 mCi) of Tc-99m-phytate was injected to the lesion under the guidance of ultrasonography. Then, the lesion was localized using a hand-held gamma probe, and excision of the lesion was performed according to its radioactivity signal. Data analysis was performed using SPSS, version 16. Results: Benign and malignant pathologic results were observed in 77 (81.9%) and 17(18.1%) of the patients, respectively, and the mean volume of the excised tissue was 26.29±27 mm³. 79 patients had a solitary lesion (84%), 55 in the left breast (58.5%) and 39 in superolateral quadrant (41.5%). The mean size of the lesions was 15.7 mm in diameter (ranging from 4 to 34 mm). Additionally, there was a need to secondary surgery in 3 (3.2%) patients and inappropriate localization in 6 (6.4%) patients (subcutaneous or intra-ductal spread of radiodrug). Conclusion: Combination of ultrasound- and radio-guided localization methods for localizing non-palpable breast lesions is a simple and acceptable method for localization with no significant complications. For radio-drug spread and subsequent excessive excised tissue volume, subcutaneous and intra-ductal lesions are not suitable indication for ROLL. %U https://aojnmb.mums.ac.ir/article_9898_8df7bb10ca26ee871ef5cc5c8edfacbd.pdf