TY - JOUR ID - 11477 TI - Dopamine Transporter imaging with Tc-99m TRODAT-1 SPECT in Parkinson’s disease and its correlation with clinical disease severity JO - Asia Oceania Journal of Nuclear Medicine and Biology JA - AOJNMB LA - en SN - 2322-5718 AU - Patel, Asra AU - Simon, Shelley AU - Elangoven, Indirani AU - Amalchandran, Jaykanth AU - Jain, Avani AU - S, Thangalakshmi AD - Department of Nuclear Medicine and PET-CT, Apollo Hospitals, Chennai, Tamilnadu, India AD - Department of Nuclear Medicine and PET-CT, Apollo Hospitals, Chennai, Tamilnadu India AD - Department of Nuclear Medicine and PET-CT Apollo Hospitals, Chennai, Tamilnadu, India AD - Department of Nuclear Medicine and PET-CT Apollo Hospitals, Chennai, Tamilnadu India Y1 - 2019 PY - 2019 VL - 7 IS - 1 SP - 22 EP - 28 KW - Tc-99m TRODAT-1 SPECT KW - Parkinson’s disease KW - Severity KW - H and Y scale KW - UPDRS DO - 10.22038/aojnmb.2018.30356.1208 N2 - Objective(s): To evaluate the role of Tc-99m TRODAT-1 Single Photon Emission Computed Tomography (SPECT) in Parkinson’s Disease (PD) by assessing the correlation of clinical disease severity, disease duration and age at onset of disease with specific uptake ratio of Tc-99m TRODAT-1 in striatum.Methods: The study included 63 patients in age range of 40-72 years with clinical diagnosis of PD and nine controls. Clinical history of patients was obtained regarding age at onset of disease and disease duration. Disease severity in each patient was assessed using H and Y stage and UPDRS. Tc-99m TRODAT-1 SPECT was performed and specific uptake ratios were calculated for six regions in bilateral striata, caudate nuclei and putamina. Difference in specific uptake ratios between different stages of disease was analyzed for statistical significance. Specific uptake ratios were correlated with UPDRS, motor score of UPDRS, duration of disease and age at onset of disease using Pearson’s correlation co-efficient.Results: Median specific uptake ratio was found to be least in contralateral putamen for all H and Y stages. There was a statistically significant difference between specific uptake ratios of controls vs stage 1, stage 1 vs 2, 1 vs 3, 1 vs 4, and 2 vs 4 for all 6 regions. The difference in uptake ratio between 3 and 4 H and Y stages was significant only for contralateralregions. There was no significant difference in uptake ratio between 2 and 3 H and Y stages. The uptake ratios showed a strong negative correlation with UPDRS and motor score, a weak negative correlation with duration of disease and no significant correlation with age at onset of disease.Conclusion: We conclude that Tc-99m TRODAT-1 SPECT can be used to assess the disease severity in PD patients. UR - https://aojnmb.mums.ac.ir/article_11477.html L1 - https://aojnmb.mums.ac.ir/article_11477_6288cb7611d4b972e7055011e19d31ac.pdf ER -