TY - JOUR ID - 14016 TI - A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques JO - Asia Oceania Journal of Nuclear Medicine and Biology JA - AOJNMB LA - en SN - 2322-5718 AU - Ayubcha, Cyrus AU - Hosoya, Hitomi AU - Mehdizadeh Seraj, Siavash AU - Zirakchian Zadeh, Mahdi AU - Werner, Thomas AU - Alavi, Abass AD - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, PA, United States AD - Department of Medicine, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA, United States Y1 - 2020 PY - 2020 VL - 8 IS - 1 SP - 64 EP - 68 KW - Polycythemia Vera KW - FDG-PET/CT KW - Myeloproliferative Neoplasm KW - Non-Invasive Procedure KW - Global Analysis DO - 10.22038/aojnmb.2019.41192.1278 N2 - Objective(s): Functional imaging presents a non-invasive process that may capture the hyper-metabolic nature of red bone marrow in myeloproliferative neoplasms, such as polycythemia vera (PV). Methods: This study analyzed the FDG-PET/CT scans (n=12) of six patients diagnosed with PV and six age-sex matched controls using a quantitative global analysis methodology. Results: All PV patients had elevated activities in the bone marrow of each skeletal structure as compared to matched controls with respect to mean standardized uptake value (femoral neck p=0.01, lumbar spine p=0.02, pelvis p=0.002, sternum p=0.04). Notable variations in splenic uptake were observed among the treated and untreated PV patients.   Conclusion: Our study exemplifies the potential utility of PET in reflecting hyperactive bone marrow activity related to PV. Future studies may further substantiate and elaborate on the use of PET-derived metabolic data in PV. UR - https://aojnmb.mums.ac.ir/article_14016.html L1 - https://aojnmb.mums.ac.ir/article_14016_10cdf2736b2993adf6af01139dcfc33d.pdf ER -