TY - JOUR ID - 14239 TI - Role of FDG-PET/CT in Assessing the Correlation Between Blood Pressure and Myocardial Metabolic Uptake JO - Asia Oceania Journal of Nuclear Medicine and Biology JA - AOJNMB LA - en SN - 2322-5718 AU - Rojulpote, Chaitanya AU - Seraj, Siavash AU - Zadeh, Mahdi AU - Yadav, Divya AU - Raynor, William AU - Kothekar, Esha AU - Al-zaghal, Abdullah AU - Werner, Thomas AU - Gerke, Oke AU - Hoilund-Carlsen, Poul AU - Alavi, Abass AD - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States AD - Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, United States AD - Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark Y1 - 2020 PY - 2020 VL - 8 IS - 1 SP - 36 EP - 45 KW - FDG KW - PET/CT KW - Myocardial metabolic uptake KW - blood pressure DO - 10.22038/aojnmb.2019.41530.1282 N2 - Objective(s): We aimed to assess the association between blood pressure and LV myocardial uptake of FDG, hypothesizing that subjects with raised blood pressure would have higher FDG uptake. Methods: We analyzed 86 healthy controls who underwent PET/CT imaging 180 minutes following FDG (4 MBq/Kg) administration. LV myocardial analysis was performed on axial sections using standard operator guided computer software (OsiriX MD). The average LV myocardial SUVmean (MSUVmean) was calculated for each subject. Subjects were assessed according to the 2017 ACC/AHA guidelines for high blood pressure in adults. Mean arterial blood pressure (MABP) was calculated for each patient. Regression models were employed for statistical analysis.  Results: The association of MSUVmean was more pronounced with DP (r=0.32, p=0.003) than SP (r=0.28, p=0.010); MABP was comparable (r=0.33, p=0.002). Correlations of MSUVmean with categorized BPs were: normal SP (r=0.27, p=0.010), elevated SP (r=0.28, p=0.009), stage 1 SP (r=0.27, p=0.010), stage 2 SP (r=0.28, p=0.008); normal DP (r=0.33, p=0.001), stage 1 DP (r=0.34, p=0.001), stage 2 DP (r=0.35, p=0.001). Multivariate analysis demonstrated DP (p=0.006), MABP (p=0.007), and SP (0.026). Conclusion: LV myocardial FDG uptake was higher in subjects with elevated blood pressure and correlated positively with SBP and in particular DBP and MABP. UR - https://aojnmb.mums.ac.ir/article_14239.html L1 - https://aojnmb.mums.ac.ir/article_14239_0cc038398e8f2aa27a23d92be521a068.pdf ER -