Effect of Beta Particles Spectrum on Absorbed Fraction in Internal Radiotherapy

Document Type: Original Article

Authors

1 Biomedical Engineering and Medical Physics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Physics Group, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran,

3 Department of Biomedical and Dental Sciences and of Morpho functional Imaging, University of Messina, Messina

4 Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, USA, Courtney

Abstract

Objective(s): The purpose of this research is to study the effect of beta spectrum on absorbed fraction ( ) and to find suitable analytical functions for beta spectrum absorbed fractions in spherical and ellipsoidal volumes with a uniform distribution for several radionuclides that are commonly used in nuclear medicine.
Methods: In order to obtain the beta particle absorbed fraction, Monte Carlo simulations were performed by using the MCNPX code. The validation of the simulations was performed by calculating the absorbed fractions in spheres and comparing the results with the data published by other investigators. The absorbed fractions were calculated and compared by using an actual beta energy spectrum with those obtained through the mean beta energy of 14C, 199Au, 177Lu, 131I, 90Sr, 153Sm, 186Re, 32P, 90Y, 38Cl and 88Rb radionuclides.
Results: The maximum difference between the absorbed fractions for beta particles accounting for the whole beta spectrum of all the considered nuclides was 29.62% with respect to the mean beta energy case. Suitable analytical relationships were found between the absorbed fraction and the generalized radius, and the dependence of the fitting parameters from beta spectrum energy was discussed and fitted by appropriate parametric functions.
Conclusion: The results allowed the calculation of the absorbed fractions from the above stated beta sources uniformly distributed in spherical and ellipsoidal volumes of any ellipticity and volume, in a wide range of practical volumes that are not only used for internal dosimetry in nuclear medicine applications, but also in radiological protection estimates of
doses from internal contamination.

Keywords

Main Subjects


1. Siegel JA, Stabin MG. Absorbed fractions for electrons and beta particles in spheres of various sizes. J Nucl Med. 1994;35(1):152-6.

2. Salek N, Shamsaei M, Ghannadi Maragheh M, Shirvani Arani S, Bahrami Samani A. Production and quality control 177Lu (NCA)-DOTMP as a potential agent for bone pain palliation. J Appl Clin Med Phys. 2016;17(6):128-39.

3. Jalili AR, Biki D, Hassanzadeh-Rad A, Eftekhari A, Geramifar P, Eftekhari M. Production and clinical applications of radiopharmaceuticals and medical radioisotopes in Iran. Semin Nucl Med. 2016;46(4):340-58.

4. Cohen VM, Papastefanou VP, Liu S, Stoker I, Hungerford JL. The use of strontium-90 Beta radiotherapy as adjuvant treatment for conjunctival melanoma. J Oncol. 2013;2013:349162.

5. Andreou M, Lagopati N, Lyra M. Re-186 and Sm- 153 dosimetry based on scintigraphic imaging data in skeletal metastasis palliative treatment and Monte Carlo simulation. J Phys Conf Ser. 2011;317(1):012013.

6. Tu SM, Lin SH, Podoloff DA, Loqothetis CJ. Multimodality therapy: bone-targeted radioisotope therapy of prostate cancer. Clin Adv Hematol Oncol.2010;8(5):341-51.

7. Stank J, Melichar F, Filyanin AT, Tomes M, Beran M. Preparation of 90YCl3 radiopharmaceutical precursor for nuclear medicine using technology of centrifugal extractors. Appl Radiat Isot. 2010;68(12):2163-8.

8. Naseri Z, Hakimi A, Jalilian AR, Nemati Kharat A, Bahrami-Samani A, Ghannadi-Maragheh M. Preparation and quality control of the [153sm]- samarium maltolate complex as a lanthanide mobilization product in rats. Sci Pharm. 2011;79(2):265-75.

9. Amato E, Lizio D, Baldari S. Absorbed fractions for electrons in ellipsoidal volumes. Phys Med Biol. 2011;56(2):357-65.

10. Mowlavi AA, Fornasier MR, Mizaei M, Breqant P, de Denaro M. Analytical functions for beta and gamma absorbed fractions of iodine-131 in spherical and ellipsoidal volumes. Ann Nucl Med. 2014;28(8):824-8.

11. Akabani G, Poston JW Sr, Bolch WE. Estimates of beta absorbed fractions in small tissue volumes for selected radionuclides. J Nucl Med. 1991;32(5):835-9.

12. Wen W, Meng-Yun C, Peng-Cheng L, Li-Qin H. Specific absorbed fractions of electrons and photons for Rad-HUMAN phantom using Monte Carlo method. Chinese Phys C. 2014;39(7):1-9.

13. Amato E, Lizio D, Baldari S. Absorbed fractions in ellipsoidal volumes for β- radionuclides employed in internal radiotherapy. Phys Med Biol. 2009;54(13):4171-80.

14. Eckerman KF, Westfall RJ, Ryman JC, Cristy M. Availability of nuclear decay data in electronic form, including beta spectra not previously published. Health Phys. 1994;67(4):338-45.

15. Bouchet LG, Bolch WE, Blanco HP, Wessels BW, Siegel JA, Rajon DA, et al. MIRD Pamphlet No 19: absorbed fractions and radionuclide S values for six age-dependent multiregion models of the kidney. J Nucl Med. 2003;44(7):1113-47.

16. Amato E, Italiano A, Baldari S. An analytical model to calculate absorbed fraction for internal dosimetry with alpha, beta and gamma emitters. Pericol Classe Sci Fis Mat Nat. 2014;92(1):A1.

17. Sgouros G. Dosimetry of internal emitters. J Nucl Med. 2005;46(1):18S-27S.

18. Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46(6):1023-7.

19. Bacher K, D’Asseler Y. Evaluation of patient-specific dosimetric methodologies for radionuclide therapy. [Master Thesis]. Ghent, Belgium: Ghent University; 2014.

20. RADAR changes the dosimetry world. The Radiation Dose Assessment Resource. Available at: URL: www. doseinfo-radar.com; Accessed on: 23/1/2017.

21. Asl RG, Parach AA, Nasseri S, Momennezhad M, Zakavi SR, Sadoughi HR. Specific absorbed fractions of internal photon and electron emitters in a human voxel-based phantom: a Monte Carlo study. World J Nucl Med. 2017;16(2):114-21.

22. Interaction of radiation with matter–environmental health. University of Toronto. Available at: URL: https://ehs.utoronto.ca/our-services/radiationsafety/radiation-protection; Accessed on: 8/1/2018.

23. International Commission on Radiation Units and Measurements. Determination of absorbed dose in a patient irradiated by beams of X or gamma rays in radiotherapy procedures. Washington: International Commission on Radiation Units and Measurements (ICRU); 1976.