Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma

Document Type : Original Article

Authors

1 Department of Nuclear Medicine, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

2 Department of Radiology, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

3 Department of Nuclear Medicine, Mugla Training and Research Hospital, Mugla Sıtkı Kocman University, Mugla, Turkey

4 Department of Nuclear Medicine, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

5 5Department of Pathology, Istanbul Bakırköy Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

6 Department of Pathology, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

7 Department of General Surgery, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

8 Department of Radiology, Istanbul Medeniyet University, Faculty of Medicine, Istanbul, Turkey

Abstract

Objective(s): Breast carcinoma is the most common type of cancer in females. This study aims to compare fluorine-18-fluorodeoxyglucose (18F-FDG) uptake pattern and apparent diffusion coefficient (ADC) value for the detection of the primary tumour and axillary metastases of invasive ductal breast carcinoma.
Methods: This study included 40 breast carcinoma lesions taken from 39 patients. After staging by positron emission tomography-computed tomography (PET/CT) and diffusion-weighted magnetic resonance imaging (MRI), breast surgery with axillary lymph node dissection or sentinel lymph node biopsy was performed.
Results: Primary lesion detection rate for PET/CT and diffusion-weighted MRI was high with 39 of 40 lesions (97.5%). The sensitivity and specificity for the detection of metastatic lymph nodes in axilla were 40.9%, 88.9%, with 18F-FDG PET/CT scans and 40.9%, 83.3%, for dw-MRI, respectively. No significant correlation was detected between ADC and SUVmax or SUVmax ratios. Estrogen receptor (p=0.007) and progesterone receptor (p=0.036) positive patients had lower ADC values. Tumour SUVmax was lower in T1 than T2 tumour size (p=0.027) and progesterone receptor-positive patients (p=0.029). Tumour/background SUVmax was lower in progesterone receptor-positive patients (p=0.004). Tumour/liver SUVmax was higher in grade III patients (p=0.035) and progesterone receptor negative status (p=0.043).
Conclusions: This study confirmed the high detection rate of breast carcinoma in both modalities. They have same sensitivity for the detection of axillary lymph node metastases, whereas the PET/CT scan had higher specificity. Furthermore, ADC, SUVmax and SUVmax ratios showed some statistical significance among the patient groups according to different pathological parameters.

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Main Subjects

References

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Asia Oceania Journal of Nuclear Medicine and Biology
Volume 12, Issue 1
January 2024
Pages 11-20

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