Document Type: Original Article
Department of Nuclear Medicine, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China
Department of Radiology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China
Guangdong Provincial Key Laboratory of Micro-nano Manufacturing Technology and Equipment, Guangdong University
of Technology, Guangzhou, China
The PET-CT Center, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Objective(s): Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm.
Methods: Three hollow models were filled with 55.0 kBq/mL fluorine18- fluorodeoxyglucose (18F-FDG) to represent tumors. The models were fixed to a barrel filled with 5.9 kBq/mL 18F-FDG to characterize normal lung tissues as a phantom. The PET/CT images of the phantom were acquired at rest. Then, the barrel was moved periodically to simulate breathing while acquiring PET/CT data. Volume recovery coefficient (VRC) was applied to evaluate the accuracy of ITVs. For statistical analysis, paired t-test and analysis of variance were applied.
Results: The VRCs ranged from 0.74 to 0.98 and significantly varied among gross tumor volumes for delineating ITV (P<0.01). In two-dimensional PET scans, the motion distance did not affect VRC (P>0.05), whereas VRC decreased with increasing distance in three-dimensional PET scans (P<0.05).
Conclusion: The threshold value (x+3×SD) had the potential to delineate the ITV of cancerous tissues, surrounded by lung tissues, particularly in two-dimensional PET images.