1Division of Medical Quantum Sciences, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu
University, Fukuoka, Japan
2Radiological Science Course, Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan
3Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan
4Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Objective(s): The aim of this study was to determine the optimal reconstruction parameters for iterative reconstruction in different devices and collimators for dopamine transporter (DaT) single-photon emission computed tomography (SPECT). The results were compared between filtered back projection (FBP) and different attenuation correction (AC) methods. Methods: An anthropomorphic striatal phantom was filled with 123I solutions at different striatum-to-background radioactivity ratios. Data were acquired using two SPECT/CT devices, equipped with a low-to-medium-energy general-purpose collimator (cameras A-1 and B-1) and a low-energy high-resolution (LEHR) collimator (cameras A-2 and B-2). The SPECT images were once reconstructed by FBP using Chang’s AC and once by ordered subset expectation maximization (OSEM) using both CTAC and Chang’s AC; moreover, scatter correction was performed. OSEM on cameras A-1 and A-2 included resolution recovery (RR). The images were analyzed, using the specific binding ratio (SBR). Regions of interest for the background were placed on both frontal and occipital regions. Results: The optimal number of iterations and subsets was 10i10s on camera A-1, 10i5s on camera A-2, and 7i6s on cameras B-1 and B-2. The optimal full width at half maximum of the Gaussian filter was 2.5 times the pixel size. In the comparison between FBP and OSEM, the quality was superior on OSEM-reconstructed images, although edge artifacts were observed in cameras A-1 and A-2. The SBR recovery of OSEM was higher than that of FBP on cameras A-1 and A-2, while no significant difference was detected on cameras B-1 and B-2. Good linearity of SBR was observed in all cameras. In the comparison between Chang’s AC and CTAC, a significant correlation was observed on all cameras. The difference in the background region influenced SBR differently in Chang’s AC and CTAC on cameras A-1 and B-1. Conclusion: Iterative reconstruction improved image quality on all cameras, although edge artifacts were observed in images captured by cameras with RR. The SBR of OSEM with RR was higher than that of FBP, while the SBR of OSEM without RR was equal to that of FBP. Also, the SBR of Chang’s AC varied with different background regions in cameras A-1 and B-1.
1. Djang DS, Janssen MJ, Bohnen N, Booij J, Henderson TA, Herholz K, et al. SNM practice guideline for dopamine transporter imaging with 123I-ioflupane SPECT 1.0. J Nucl Med. 2012;53(1):154-63.
2. Darcourt J, Booij J, Tatsch K, Varrone A, Vander Borght T, Kapucu OL, et al. EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2. Eur J Nucl Med Mol Imaging. 2010;37(2):443-50.
3. O’Sullivan JD, Lees AJ. Nonparkinsonian tremors. Clin Neuropharmacol. 2000;23(5):233-8.
4. Furukawa Y, Kish SJ. Dopa-responsive dystonia: recent advances and remaining issues to be addressed. Mov Disord. 1999;14(5):709-15.
5. Tissingh G, Bergmans P, Booij J, Winogrodzka A, Stoof JC, Wolters EC, et al. [123I]beta-CIT single-photon emission tomography in Parkinson’s disease reveals a smaller decline in dopamine transporter s with age than in controls. Eur J Nucl Med. 1997;24(9):1171-4.
6. Lavalaye J, Booij J, Reneman L, Habraken JB, van Royen EA. Effect of age and gender on dopamine transporter imaging with [123I]-FP-CIT SPET in healthy volunteers. Eur J Nucl Med. 2000;27(7):867-9.
7. Tissingh G, Booij J, Bergmans P, Winogrodzka A, Janssen AG, van Royen EA, et al. Iodine-123-N-omega-fluoropropyl-2beta- carbomethoxy-3beta- (4-iod ophenyl)tropane SPECT in healthy controls and early-stage, drug-naive Parkinson’s disease. J Nucl Med. 1998;39(7):1143–8.
8. Booij J, Habraken JB, Bergmans P, Tissingh G, Winogrodzka A, Wolters EC, et al. Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson’s disease. J Nucl Med. 1998;39(11):1879–84.
9. Seibyl JP, Marek K, Sheff K, Zoghbi S, Baldwin RM, Charney DS, et al. Iodine-123-beta-CIT and iodine- 123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson’s patients. J Nucl Med. 1998;39(9):1500–8.
10. Badiavas K, Molyvda E, Iakovou I, Tsolaki M, Psarrakos K, Karatzas N. SPECT imaging evaluation in movement disorders: far beyond visual assessment. Eur J Nucl Med Mol Imaging. 2011;38(4):764–73.
11. Soret M, Koulibaly PM, Darcourt J, Hapdey S, Buvat I. Quantitative accuracy of dopaminergic neurotransmission imaging with (123)I SPECT. J Nucl Med. 2003;44(7):1184-93.
12. Pareto D, Cot A, Pavı´a J, Falcón C, Juvells I, Lomeña F, et al. Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission SPET imaging. Eur J Nucl Med Mol Imaging. 2003;30(10):1322–9.
13. Maebatake A, Sato M, Kagami R, Yamashita Y, Komiya I, Himuro K, et al. An anthropomorphic phantom study of brain dopamine transporter SPECT images obtained using different SPECT/ CT devices and collimators. J Nucl Med Technol. 2015;43(1):41-6.
14. Ishii K, Hanaoka K, Okada M, Kumano S, Komeya Y, Tsuchiya N, et al. Impact of CT attenuation correction by SPECT/CT in brain perfusion images. Ann Nucl Med. 2012;26(3):241-7.
15. Vija HA, Hawman EG, Engdahl JC. Analysis of a SPECT OSEM reconstruction method with 3D beam modeling and optional attenuation correction: phantom studies. IEEE Nucl Sci Symp Conf Record. 2003;4:2662-6.
16. Winz OH, Hellwig S, Mix M, Weber WA, Mottaghy FM, Schäfer WM, et al. Image quality and data quantification in dopamine transporter SPECT: advantage of 3-dimentional OSEM reconstruction? Clin Nucl Med. 2012;37(9):866-71.
17. Onishi H, Motomura N, Fujino K, Natsume T, Haramoto Y. Quantitative performance of advanced resolution recovery strategies on SPECT images: evaluation with use of digital phantom models. Radiol Phys Technol. 2013;6(1):42-53.
18. Dickson JC, Tossici-Bolt L, Sera T, Erlandsson K, Varrone A, Tatsch K, et al. The impact of reconstruction method on the quantification of DaTSCAN images. Eur J Nucl Med Mol Imaging. 2010;37(1):23-35.
19. He X, Frey EC, Links JM, Song X, Tsui BM. Comparison of penetration and scatter effects on defects on defect contrast for GE and Siemens LEHR collimators in myocardial perfusion SPECT a simulation study. IEEE Trans Nucl Sci. 2005;52(5):1359-64.
20. Bieńkiewicz M, Górska-Chrzastek M, Siennicki J, Gajos A, Bogucki A, Mochecka-Thoelke A, et al. Impact of CT based attenuation correction on quantitative assessment of DaTSCAN ((123)I-Ioflupane) imaging in diagnosis of extrapyramidal diseases. Nucl Med Rev Cent East Eur. 2008;11(2):53-8.
21. Lange C, Seese A, Schwarzenböck S, Steinhoff K, Umland-Seidler B, Krause BJ, et al. CT-based attenuation correction in I-123-ioflupane SPECT. PLoS ONE. 2014;9(9):e108328.