RetroSPECT: Gallium-67 as a Long-Lived Imaging Agent for Theranostics
Dale
Bailey
Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia
author
Dhanusha
Sabanathan
GlyTherix Ltd, Sydney, Australia
author
Alireza
Aslani
Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia
author
Douglas
Campbell
GlyTherix Ltd, Sydney, Australia
author
Bradley
Walsh
GlyTherix Ltd, Sydney, Australia
author
Nigel
Lengkeek
Biosciences, Australian Nuclear Science & Technology Organisation (ANSTO), Sydney, Australia
author
text
article
2021
eng
A limitation to the wider introduction of personalised dosimetry in theranostics is the relative paucity of imaging radionuclides with suitable physical and chemical properties to be paired with a long-lived therapeutic partner. As most of the beta-emitting therapeutic radionuclides emit gamma radiation as well they could potentially be used as the imaging radionuclide as well as the therapeutic radionuclide. However, the downsides are that the beta radiation will deliver a significant radiation dose as part of the treatment planning procedure, and the gamma radiation branching ratio is often quite low. Gallium-67 has been in use in nuclear medicine for over 50 years. However, the tremendous interest in gallium imaging in theranostics in recent times has focused on the PET radionuclide gallium-68. In this article it is suggested that the longer-lived gallium-67, which has desirable characteristics for imaging with the gamma camera and a suitably long half-life to match biological timescales for drug uptake and turnover, has been overlooked, in particular, for treatment planning with radionuclide therapy. Gallium-67 could also allow non-PET facilities to participate in theranostic imaging prior to treatment or for monitoring response after therapy. Gallium-67 could play a niche role in the future development of personalised medicine with theranostics.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
1
8
https://aojnmb.mums.ac.ir/article_16950_7245afb4cba26e878f194b33e4e5271f.pdf
dx.doi.org/10.22038/aojnmb.2020.51714.1355
Sentinel lymph node biopsy for papillary thyroid cancer: the effect of dose, tracer and application of massage
Abbas
Alibakhshi
Department of surgery, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Saeed
Farzanehfar
Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Mahya
Zarei
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Mohammad
Eftekhari
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Maziar
Motiee
Department of Otolaryngology–Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
author
Maryam
Naseri
Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Mehrshad
Abbasi
Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
text
article
2021
eng
Objective(s): In patients with papillary thyroid cancer (PTC), sentinel lymph node (SLN) radio-guided biopsy is not routinely used for detection of involved neck lymph nodes (NLN); 99mTc- antimony sulfide colloid (99mTc- ASC) has been used for this purpose. In this study, besides 99mTc-ASC another radiotracer, 99mTc-phytate (99mTc-P) with different doses and injection methods were evaluated.
Methods: Twenty-two patients, scheduled to undergo thyroidectomy for PTC, were injected for radio-guided SLN biopsy in the morning of operation in 3 groups: intra tumoral injection of about 1 mCi 99mTc-P (group A; n=5); peritumoral injection of less than 3 mCi 99mTc-ASC (group B; n=6); and peritumoral injection of 3 to 5 mCi 99mTc-ASC with application of massage (group C; n=9). A patient refused to complete the study. A patient with follicular thyroid cancer was also excluded. No NLN was detected in the pre-operative ultra-sonographic examinations of all patients. Central neck dissection was done for all the participants. The presence of radio guided detected NLN and results of pathology were assessed.
Results: In group A and B, no SLN was detected. NLNs were resected in 4 patients in group A and B; 2 of them involved by the tumor. In group C, 6 out of 9 patients (66.7%) had between 1 to 6 SLNs; the procedure failed to detect NLN in a patient in group C with surgically resected reactive NLN (failure rate 1 out of 7).
Conclusion: The results underscored the significance of SLN radio guided biopsy in patients with PTC; the radiotracer, dose and method of injection may affect the detection rate.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
9
14
https://aojnmb.mums.ac.ir/article_16761_09bdaf5e1ba2143d1811bba82425769f.pdf
dx.doi.org/10.22038/aojnmb.2020.50491.1345
Physiological FDG uptake in growth plate on pediatric PET
Tomoaki
Otani
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Japan
author
Yuji
Nakamoto
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Japan
author
Takayoshi
Ishimori
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Japan
author
text
article
2021
eng
Objective(s):18F-Fluorodeoxyglucose (FDG) uptake in children is different from that in adults. Physiological accumulation is known to occur in growth plates, but the pattern of distribution has not been fully investigated. Our aim was to evaluate the metabolic activity of growth plates according to age and location.
Methods:We retrospectively evaluated 89 PET/CT scans in 63 pediatric patients (male : female=25 : 38, range, 0–18 years). Patients were classified into four age groups (Group A: 0–2 years, Group B: 3–9 years, Group C: 10–14 years and Group D: 15-18 years). The maximum standardized uptake value (SUVmax) of the proximal and distal growth plates of the humerus, the forearm bones and the femur were measured. The SUVmax of each site and each age group were compared and statistically analyzed. We also examined the correlations between age and SUVmax.
Results:As for the comparison of SUVmax in each location, the SUVmax was significantly higher in the distal femur than those in the other sites (p< 0.01). SUVmax in the distal humerus and the proximal forearm bones were significantly lower than those in the other sites (p< 0.01). In the distal femur, there was large variation in SUVmax, while in the distal humerus and the proximal forearm bones, there was small variation. As for the comparison of SUVmax in each age group, the SUVmax in group D tended to be lower than those in the other groups, but in the distal femur, there was no significant difference among each age group.
Conclusion:Our data indicate that FDG uptake in growth plates varies depending on the site and age with remarkable uptake especially in the distal femur.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
15
20
https://aojnmb.mums.ac.ir/article_16522_8f7b0ee422e130ad2aacc9013a7a7857.pdf
dx.doi.org/10.22038/aojnmb.2020.49638.1339
18F-THK 5351 and 11C-PiB PET of the Thai normal brain template
Chanisa
Chotipanich
National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
author
Supaporn
Kongthai
National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
author
Anchisa
Kunawudhi
National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
author
Chetsadaporn
Promteangtrong
National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
author
Attapon
Jantarato
National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
author
text
article
2021
eng
Objective(s): The aim of the study was to create a local normal database brain template of Thai individuals for 11C-Pittsburgh compound B (11C-PiB) and 18F-THK 5351 depositions using statistical parametric mapping (SPM) software, and to validate and optimize the established specific brain template for use in clinical practice with a highly reliability and reproducibility.
Methods: This prospective study was conducted in 24 healthy right-handed volunteers (13 men, 11 women; aged: 42–79 years) who underwent 18F-THK 5351 and 11C-PiB PET/CT scans. SPM was used for the 18F-THK 5351 and 11C-PiB PET/CT image analysis. All PET images were processed individually using Diffusion Tensor Image -Magnetic Resonance Imaging-weighted images (DTI-MRI images), which involved: (1) conversion of Digital Imaging and Communications in Medicine (DICOM) files into an analyzable file extension (.NIFTI) for statistical parametric mapping, (2) setting of the origin (the anterior commissure was used as the anatomical landmark), (3) re-alignment, (4) co-registration of PET with B0 (T1W) and DTI-MRI images, (5) normalization, and (6) normal verification using the Thai MRI standard. We then compared the normal PET template with the abnormal deposition area of different dementia syndromes, including Alzheimer’s disease and progressive supranuclear palsy.
Results: This method was able to differentiate cognitively normal from Alzheimer’s disease and progressive supranuclear palsy subjects .
Conclusions: This normal brain template was able to be integrated into clinical practice and research using PET analyses at our center.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
21
30
https://aojnmb.mums.ac.ir/article_16771_880155f242139fd64173e09d2399d24a.pdf
dx.doi.org/10.22038/aojnmb.2020.49623.1338
CT Attenuation correction and its impact on image quality of myocardial perfusion imaging in coronary artery disease: A systematic review
Claire
Farrell
Department of Medical Imaging, Medical Radiations and Nuclear Medicine, Eastern Health, Victoria, Australia
author
Jo-Anne
Pinson
Department of Medical Imaging, Monash Health, Peninsula Health, Victoria, Australia
author
Amy
Dennett
School of Allied Health, Human Services and Sport, La Trobe University, Allied Health Clinical Research Office, Eastern Health, Victoria, Australia
author
text
article
2021
eng
Myocardial perfusion imaging is a non-invasive procedure that plays an integral role in the diagnosis and management of coronary artery disease. With the routine use of computerised tomography attenuation correction (CTAC) in myocardial perfusion imaging still under debate, the aim of this review was to determine the impact of CTAC on image quality in myocardial perfusion imaging. Medline, Embase and CINAHL were searched from the earliest available time until August 2019. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies version 2. Details pertaining to image quality and diagnostic accuracy were analysed, and results summarised descriptively. Three studies with ‘unclear’ risk of bias and low applicability concerns (1002 participants) from a yield of 2725 articles were identified. Two studies demonstrated an increase in image quality, and one study found no difference in image quality when using CTAC compared to no attenuation correction. Benefits of CTAC for improving image quality remain unclear. Given the potential exposure risk with the addition of CTAC, patient and clinician factors should inform decision making for use of CTAC in myocardial perfusion imaging for coronary artery disease.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
31
38
https://aojnmb.mums.ac.ir/article_16766_02a01bf27e0092e0c1955d760834ea3b.pdf
dx.doi.org/10.22038/aojnmb.2020.50692.1346
Extensive Extranodal Involvement in a case of Non-Hodgkin's Lymphoma with sparing of lymph nodes and lymphatic organs
vijay
singh
Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
India
author
akshay
kumar
Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
India
author
prakash
singh
Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
India
author
manish
ora
Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
India
author
Sanjay
Gambhir
Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
India
author
text
article
2021
eng
Non-Hodgkin lymphoma (NHL) is a group of malignant lymphoproliferative disorders arising predominantly in the lymph nodes with various clinical and histological characteristics. At least 25% of NHL originates from tissues other than lymph nodes and sometimes even from sites that do not contain lymphoid tissue. These are referred to as primary extranodal lymphomas (pENLs). pENL is a universal diagnostic challenge to the clinicians and pathologists due to their varied clinical presentations, morphological mimicry, and molecular alterations. The GIT is the most common site of pENL followed by nasopharynx/oropharynx, testis, uterus/ovary, thyroid, and central nervous system. Long bones (tibia), maxillary sinus, skin, and paraspinal soft tissues are the other rare anatomic sites of pENL. We reported a case of a 60-year-old female presented with pain and mass in the pelvis region. 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and fused PET/CT was done, which revealed extensive extranodal involvement of the lung, bilateral kidneys, uterus, ovaries, bones, and muscles with no involvement of lymph nodes or lymphomatous organs. Extensive extranodal involvement with sparing of lymphomatous organ has not been reported earlier.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
39
44
https://aojnmb.mums.ac.ir/article_16523_09f3af9790fa39479fa50b50dfd316dc.pdf
dx.doi.org/10.22038/aojnmb.2020.47774.1324
Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression
NIKITA
SAMPATHIRAO
Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India
author
Indirani
Muthukrishnan
Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India
author
Ann
Kurian
Department of Pathology, Apollo Hospitals, Chennai, India
author
Jaykanth
Amalchandran
Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India
author
Asra
Patel
Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India
author
shema
mathew
Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India
author
Shelley
Simon
Department of Nuclear Medicine and PET/CT, Apollo Hospitals, Chennai, India
author
text
article
2021
eng
High-grade B-cell lymphoma, an aggressive form of Non-Hodgkin’s Lymphoma, is known as a double or triple hit lymphoma based on the presence of MYC and BCL2 without or with BCL6 genetic rearrangements, respectively. It carries a poorer prognosis, compared to other variants of B-cell lymphoma, and its management also differs which requires more intensive chemotherapy in contrast to the routine regimen. Terminal deoxynucleotidyl transferase (TdT), a marker of immaturity is commonly expressed in B-cell lymphoblastic leukemia or lymphoma (B cell ALL) which is absent in mature forms of B-cell lymphoma. The TdT is expressed in high-grade B-cell lymphoma; therefore, it poses a classification and management dilemma, which should be accurately differentiated from B-cell ALL and mandates molecular analysis. Herein, we report a case of a 52-year-old female with biopsy reported as high-grade B-cell lymphoma with TdT expression. She was referred for Fluor-deoxyglucose (FDG) Positron Emission Tomography-Computed Tomography (PET/CT) scan for staging in the absence of molecular analysis for B-cell ALL. It was diagnosed as lymphoma on FDG PET/CT based on its characteristic findings of extensive extranodal involvement of multiple organs with no significant lymphadenopathy establishing the incremental value of FDG PET/CT scan, which helped the clinician to arrive at a conclusion.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
45
50
https://aojnmb.mums.ac.ir/article_16764_d6e748c19d7464d40d40b418b38e5cf3.pdf
dx.doi.org/10.22038/aojnmb.2020.48887.1332
Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic
Ananya
Panda
Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
author
Michael
McCarthy
Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA
author
Joseph
Murray
Departments of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
author
Rosalind
Sharain
Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA
author
Min
Shi
Departments of Pathology, Mayo Clinic, Rochester, Minnesota, USA
author
Ayse
Kendi
Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
author
text
article
2021
eng
Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or extra-intestinal manifestations. Typical 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) gastrointestinal manifestations of celiac disease include increased multifocal or diffuse jejunal and ileal uptake; focal duodenal uptake is less common. Splenomegaly with increased splenic FDG uptake is also uncommon in celiac disease in the absence of portal hypertension; small-sized spleen and functional hyposplenism are more typical. We report a case of celiac disease diagnosed after PET/CT showed FDG uptake in the duodenum and enlarged spleen. Follow-up after gluten-free diet showed complete metabolic resolution and regression of splenomegaly. The combination of focal bowel and splenic uptake is unusual in celiac disease and may be mistaken for a lymphoproliferative disorder. Awareness of this entity may avoid misdiagnosis and guide appropriate management.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
51
55
https://aojnmb.mums.ac.ir/article_16763_94cd9b431350fd07c2abb5555a1db4d8.pdf
dx.doi.org/10.22038/aojnmb.2020.49000.1333
18F-FDG PET/CT in the Evaluation of Solitary Extramedullary Plasmacytoma: A Case Series
Swati
Rachh
Department of Nuclear Medicine, Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, Gujarat, India
author
Ketul
Puj
Department of Surgical Oncology, Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, Gujarat, India
author
Ankita
Parikh
Department of Radiation Oncology, Gujarat Cancer and Research Institute, Asarwa, Ahmedabad,Gujarat, India
author
text
article
2021
eng
The role of fluorine-18-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) in patients with multiple myeloma (MM) and other plasma cell disorders is well-known. Solitary plasmacytoma (SP), an extremely rare form within this entity accounting for approximately 4% of plasma cell malignancies, can be classified as solitary bone plasmacytoma (SBP) or solitary extramedullary plasmacytoma (SEMP). Extramedullary plasmacytoma (EMP) is a rare neoplasm characterized by the monoclonal proliferation of plasma cells outside the bone marrow. Breast and craniocerebral regions are the uncommon sites of the presentations of EMP, rarely reported in the literature. The most frequent site of presentation is the upper airways. The EMPs have similar pathogenesis as MM; however, they differ in management as they are radiosensitive in nature, and radiotherapy is the preferred treatment modality. As SEMP has a better prognosis than SPB with a lower conversion rate to MM, accurate staging is essential to plan for the treatment. The 18F-FDG PET/CT has higher sensitivity for the evaluation of treatment response. In the present case series, it was aimed to depict the role of 18F-FDG PET/CT in newly diagnosed SEMP with different sites of origin to exclude further lesions leading to changes in the treatment plan and treatment response assessment.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
56
61
https://aojnmb.mums.ac.ir/article_16762_64b909b0fcd148c7a3f0318c2b602b35.pdf
dx.doi.org/10.22038/aojnmb.2020.49226.1335
Potential role of 18F-FDG PET/CT in a case of progressive Rosai Dorfman disease
Armaghan
Fard-Esfahani
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Bahare
Saidi
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Sara
Seyedinia
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Alireza
Emami Ardekani
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
Mohammad
Eftekhari
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
author
text
article
2021
eng
Rosai Dorfman disease is a rare form of nonlangerhans cell histiocytosis, presenting with extensive lymphadenopathies. Treatment in most cases of nodal disease, involves close observation; however, extranodal involvement requires a more definitive treatment strategy. Herein, we report a case of extensive Rosai Dorfman disease in a 43-year-old woman presenting for evaluation of treatment response by 18F-FDG PET/CT after frequent relapses and disease progression. In addition to extensive lymphadenothapies in cervical, supraclavicular, superior mediastinum, axillary, abdominopelvic and inguinofemoral regions, the patient had metabolically active bone and subcutaneous lesions which were not previously recognized. Following this 18F-FDG PET/CT study, the patient management was changed to sirolimus and prednisolone. To choose the best treatment option for Rosai Dorfman patients, knowledge of the full extent of disease is important. Compared with conventional imaging, 18F-FDG PET/CT has the advantage of being a whole-body imaging modality and can recognize disease involvement prior to any anatomical changes.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
62
66
https://aojnmb.mums.ac.ir/article_16895_eaa8096ee2f91e08e65d20212cd25675.pdf
dx.doi.org/10.22038/aojnmb.2020.51742.1356
Orbital and brain metastases on 68Ga-PSMA PET/CT in a patient with prostate carcinoma refractory to 177Lu-PSMA and 225Ac-PSMA therapy
Ashwin Singh
Parihar
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
author
Kunal
Chandekar
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
author
Harpreet
Singh
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
author
Ashwani
Sood
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
author
Bhagwant
Mittal
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
author
text
article
2021
eng
We present a case of metastatic prostate cancer with rare metastases involving the brain and orbit, in addition to liver, skeletal and nodal metastases. The patient had undergone prior hormonal therapy and chemotherapy and had disease progression despite 2 cycles of 177Lu-Prostate specific membrane antigen (177Lu-PSMA) based radioligand therapy. He had a partial response after 2 cycles of 225Ac-PSMA based targeted alpha therapy, as demonstrated on the 68Ga-PSMA PET/CT study. However, the patient had disease progression at the end of 4 cycles of 225Ac-PSMA therapy, evident by rising prostate specific antigen levels and imaging findings. The end of treatment 68Ga-PSMA PET/CT showed additional sites of metastases in the orbit and brain apart from overall disease progression. These are rare sites of distant spread in prostate cancer and require urgent evaluation and local treatment to prevent potential complications. The importance of detection of metastatic sites in closed cavities is because of the requirement for urgent intervention to avoid compression related complications.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
67
70
https://aojnmb.mums.ac.ir/article_16769_413113d44db458fbafbe7be4fd8a6828.pdf
dx.doi.org/10.22038/aojnmb.2020.50820.1347
A case of cardiac amyloidosis incidentally detected by bone scintigraphy
Hiroki
Tanaka
Department of Diagnostic Radiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
author
Makoto
Hosono
Department of Radiology, Kindai University Faculty of Medicine, Osaka, Japan
author
Mitsunori
Kanagaki
Department of Diagnostic Radiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
author
Marina
Shimizu
Department of Diagnostic Radiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
author
Naoko
Matsubara
Department of Diagnostic Radiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
author
Kazuna
Kawabata
Department of Diagnostic Radiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
author
Tadashi
Miyamoto
Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan
author
Kazumi
Itoi
Department of Respiratory Surgery, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
author
text
article
2021
eng
A 73-year-old man with lung cancer underwent bone scintigraphy for disease staging. Diffuse myocardial technetium hydroxymethylene diphosphonate (99mTc-HMDP) uptake was incidentally found. A diagnosis of amyloid transthyretin (ATTR) cardiac amyloidosis was suspected, although the patient had no symptoms at this time. Single-photon emission computed tomography (SPECT) showed particularly strong uptake in the ventricular septum. Cardiac magnetic resonance imaging (CMR) showed widespread subendocardial and partly transmural enhancement of the left ventricular myocardium on delayed postcontrast T1-weighted images. These findings were consistent with ATTR cardiac amyloidosis. 18F-FDG uptake in the left ventricle wall was observed on PET/CT. He was finally diagnosed with ATTR by endomyocardial biopsy. There are two major subtypes of cardiac amyloidosis: ATTR amyloidosis and amyloid light-chain (AL) amyloidosis. Endomyocardial biopsy is the gold standard for diagnosis. Recently, however, several reports have shown that bone scintigraphy using a 99mTc-labelled bone-seeking agent can detect ATTR cardiac amyloidosis and differentiate it from AL amyloidosis. Bone scintigraphy may play an important role in the detection and differentiation of ATTR cardiac amyloidosis.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
71
75
https://aojnmb.mums.ac.ir/article_16765_be25a7060fd0218728decf1e162f89db.pdf
dx.doi.org/10.22038/aojnmb.2020.50508.1350
Unusual presentation of lumbar chordoma on bone scintigraphy in a young patient
Yasaman
Fakhar
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran
author
Golnaz
Gholami
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran
author
Zahra
Bakhshi golestani
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran
author
Ramin
Sadeghi
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran
author
Vahidreza
Dabbagh Kakhki
Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran
author
text
article
2021
eng
Chordoma is a rare bone cancer which arises from undifferentiated notochordal remnants in the axial skeleton. It generally has slow-growing and locally aggressive behavior. This tumor is usually diagnosed by CT and MRI modalities and the role of SPECT/CT is still debated. It shows reduced or normal uptake of radioisotope on bone scanning and increased tracer uptake is infrequently reported. Here we present a 33-year-old man with complaint of low back pain and numbness of his right leg. The whole body bone scan showed relatively uniform radiotracer activity throughout the skeleton. A focal increased uptake in the second lumbar vertebra was noted on SPECT/CT images. SPECT/CT also demonstrated multiple lytic lesions in lumbar vertebrae. The lesions were proven to be chordoma on biopsy. Lumbar chordoma could be one of the differential diagnoses for lytic lesions of the vertebrae which show absent or minimal tracer uptake on bone scintigraphy and SPECT/CT imaging. Our case was unusual as the patient was very young for chordoma diagnosis and bone scan showed increased uptake adjacent to the involved vertebral lesion detected by SPECT/CT.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
76
79
https://aojnmb.mums.ac.ir/article_16842_bbe615b6793aaed2861edfab55cf90ee.pdf
dx.doi.org/10.22038/aojnmb.2020.48929.1331
A Path to New Normal of Nuclear Medicine Facilities: Considerations for Reopening
Farhad
Abbasi
Department of Infectious Diseases, Bushehr University of Medical Sciences, Bushehr, Iran
author
Ali
Gholamrezanezhad
Department of Diagnostic Radiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
author
narges
jokar
Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
author
Majid
Assadi
Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
author
text
article
2021
eng
The stormy clouds of the coronavirus disease 2019 outbreak caused a rapidly spreading epidemic still hanging over the sphere. Any steps to transition toward a new normal should be guided by health authorities, together with economic and societal considerations. There are various items mainly falling into three classifications, including patient worry, clinical demand, and economic recession. Social distancing, lay-offs, and decreased number of patients with health insurance may lead to a prolonged period to retrieve normalcy. To return to a new normal, an individualized management model should be developed for each laboratory based on staff, instruments, services, crowding, physical space, hospital base unit, or outpatient clinic. Continuous training of different occupational staffs is among the key parameters in maintaining this readiness. The proposed response model should have internal and systemic integrity as well as coherence among the included items in two intra- and inter-unit management categories, namely thinking globally and acting locally.
Asia Oceania Journal of Nuclear Medicine and Biology
Mashhad University of Medical Sciences in collaboration with
AOFNMB
2322-5718
9
v.
1
no.
2021
80
85
https://aojnmb.mums.ac.ir/article_16887_506bbcb37269c550b4f6f92930864302.pdf
dx.doi.org/10.22038/aojnmb.2020.16887