@article { author = {Ayubcha, Cyrus and Hosoya, Hitomi and Mehdizadeh Seraj, Siavash and Zirakchian Zadeh, Mahdi and Werner, Thomas and Alavi, Abass}, title = {A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques}, journal = {Asia Oceania Journal of Nuclear Medicine and Biology}, volume = {8}, number = {1}, pages = {64-68}, year = {2020}, publisher = {Mashhad University of Medical Sciences in collaboration with AOFNMB}, issn = {2322-5718}, eissn = {2322-5726}, doi = {10.22038/aojnmb.2019.41192.1278}, abstract = {Objective(s): Functional imaging presents a non-invasive process that may capture the hyper-metabolic nature of red bone marrow in myeloproliferative neoplasms, such as polycythemia vera (PV). Methods: This study analyzed the FDG-PET/CT scans (n=12) of six patients diagnosed with PV and six age-sex matched controls using a quantitative global analysis methodology. Results: All PV patients had elevated activities in the bone marrow of each skeletal structure as compared to matched controls with respect to mean standardized uptake value (femoral neck p=0.01, lumbar spine p=0.02, pelvis p=0.002, sternum p=0.04). Notable variations in splenic uptake were observed among the treated and untreated PV patients.   Conclusion: Our study exemplifies the potential utility of PET in reflecting hyperactive bone marrow activity related to PV. Future studies may further substantiate and elaborate on the use of PET-derived metabolic data in PV.}, keywords = {Polycythemia Vera,FDG-PET/CT,Myeloproliferative Neoplasm,Non-Invasive Procedure,Global Analysis}, url = {https://aojnmb.mums.ac.ir/article_14016.html}, eprint = {https://aojnmb.mums.ac.ir/article_14016_10cdf2736b2993adf6af01139dcfc33d.pdf} }