@article { author = {SAMPATHIRAO, NIKITA and Muthukrishnan, Indirani and Kurian, Ann and Amalchandran, Jaykanth and Patel, Asra and mathew, shema and Simon, Shelley}, title = {Incremental Value of FDG PET/CT in Aggressive High Grade B Cell lymphoma with TdT Expression}, journal = {Asia Oceania Journal of Nuclear Medicine and Biology}, volume = {9}, number = {1}, pages = {45-50}, year = {2021}, publisher = {Mashhad University of Medical Sciences in collaboration with AOFNMB}, issn = {2322-5718}, eissn = {2322-5726}, doi = {10.22038/aojnmb.2020.48887.1332}, abstract = {High-grade B-cell lymphoma, an aggressive form of Non-Hodgkin’s Lymphoma, is known as a double or triple hit lymphoma based on the presence of MYC and BCL2 without or with BCL6 genetic rearrangements, respectively. It carries a poorer prognosis, compared to other variants of B-cell lymphoma, and its management also differs which requires more intensive chemotherapy in contrast to the routine regimen. Terminal deoxynucleotidyl transferase (TdT), a marker of immaturity is commonly expressed in B-cell lymphoblastic leukemia or lymphoma (B cell ALL) which is absent in mature forms of B-cell lymphoma. The TdT is expressed in high-grade B-cell lymphoma; therefore, it poses a classification and management dilemma, which should be accurately differentiated from B-cell ALL and mandates molecular analysis. Herein, we report a case of a 52-year-old female with biopsy reported as high-grade B-cell lymphoma with TdT expression. She was referred for Fluor-deoxyglucose (FDG) Positron Emission Tomography-Computed Tomography (PET/CT) scan for staging in the absence of molecular analysis for B-cell ALL. It was diagnosed as lymphoma on FDG PET/CT based on its characteristic findings of extensive extranodal involvement of multiple organs with no significant lymphadenopathy establishing the incremental value of FDG PET/CT scan, which helped the clinician to arrive at a conclusion.}, keywords = {TdT expression,extranodal B cell lymphoma,FDG PET/CT}, url = {https://aojnmb.mums.ac.ir/article_16764.html}, eprint = {https://aojnmb.mums.ac.ir/article_16764_d6e748c19d7464d40d40b418b38e5cf3.pdf} }