@article { author = {Singh, Vijay and Dixit, Shivangi and Ora, Manish and Nazar, Aftab}, title = {Metabolic flare phenomenon mimicking disease progression on 18Flouride– Fluorodeoxyglucose PET/CT scan in breast cancer treated with paclitaxel-based chemotherapy}, journal = {Asia Oceania Journal of Nuclear Medicine and Biology}, volume = {11}, number = {2}, pages = {175-180}, year = {2023}, publisher = {Mashhad University of Medical Sciences in collaboration with AOFNMB}, issn = {2322-5718}, eissn = {2322-5726}, doi = {10.22038/aojnmb.2022.68237.1474}, abstract = {18F-fluorodeoxyglucose Positron emission tomography (18F-FDG PET/CT ) is now being used as a single modality for metastatic workup and response evaluation in breast cancer. An increase in metabolic activity indicates disease progression; however, metabolic flare should be kept in mind. Metabolic flare is a well-documented phenomenon reported in metastatic breast and prostate cancer. Despite a favorable response to therapy, there is a paradoxical increase in radiopharmaceutical uptake. The flare phenomenon with various chemotherapeutic and hormonal agents is well acknowledged in bone scintigraphy. However, very few cases have been documented on PET/CT. Increased uptake may be noted after treatment is instituted. The increased osteoblastic activity is associated with the healing response of bone tumors. We report a case of treated breast cancer. She presented with metastatic recurrence after four years of initial management. The patient was started on paclitaxel chemotherapy. Serial 18F- FDG PET/CT demonstrated metabolic flare and complete metabolic response.}, keywords = {Flare phenomenon,Paclitaxel,Breast Cancer}, url = {https://aojnmb.mums.ac.ir/article_21344.html}, eprint = {https://aojnmb.mums.ac.ir/article_21344_3dc38655a0a5c75f099e047df6962c7a.pdf} }