%0 Journal Article %T Combination of compressed sensing-based iterative reconstruction and offset acquisition for I-123 FP-CIT SPECT: a simulation study %J Asia Oceania Journal of Nuclear Medicine and Biology %I Mashhad University of Medical Sciences in collaboration with AOFNMB %Z 2322-5718 %A Matsutomo, Norikazu %A Hashimoto, Takeyuki %A Fukami, Mistuha %A Yamamoto, Tomoaki %D 2022 %\ 06/01/2022 %V 10 %N 2 %P 117-125 %! Combination of compressed sensing-based iterative reconstruction and offset acquisition for I-123 FP-CIT SPECT: a simulation study %K Compressed sensing %K rapid acquisition %K dynamic SPECT %K dopamine transporter imaging %K SPECT reconstruction %R 10.22038/aojnmb.2021.59585.1417 %X Objective(s): The purpose of this study was to validate undersampled single-photon emission computed tomography (SPECT) imaging using a combination of compressed sensing (CS) iterative reconstruction (CS-IR) and offset acquisition.Methods: Three types of numerical phantoms were used to evaluate image quality and quantification derived from CS with offset acquisition. SPECT images were reconstructed using filtered back-projection (FBP), maximum likelihood-expectation maximization (ML-EM), CS-IR, and CS-IR with offset acquisition. The efficacy of CS-IR with offset acquisition was examined in terms of spatial resolution, aspect ratio (ASR), activity concentration linearity, contrast, percent coefficient of variation (%CV), and specific binding ratio (SBR).Results: The full widths at half maximum remained unchanged as the number of projections decreased in CS-IR with offset acquisition. Changes in ASRs and linearities of count density were observed for ML-EM and CS-IR from undersampled projections. The %CV obtained by CS-IR with offset acquisition was substantially lower than that obtained by ML-EM and CS-IR. There were no significant differences between the %CVs obtained from 60 projections by CS-IR with offset acquisition and from 120 projections by FBP. Although the SBRs for CS-IR with offset acquisition tended to be slightly lower than for FBP, the SBRs for CS-IR with offset acquisition did not change with the number of projections.Conclusions: CS-IR with offset acquisition can provide good image quality and quantification compared with a commonly used SPECT reconstruction method, especially from undersampled projection data. Our proposed method could shorten overall SPECT acquisition times, which would benefit patients and enable quantification with dynamic SPECT acquisitions. %U https://aojnmb.mums.ac.ir/article_19613_d18c0282c74188cf26addb7bd6216d54.pdf