%0 Journal Article %T Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome %J Asia Oceania Journal of Nuclear Medicine and Biology %I Mashhad University of Medical Sciences in collaboration with AOFNMB %Z 2322-5718 %A Takenaka, Junki %A Hirata, Kenji %A Watanabe, Shiro %A Shiraishi, Hideaki %A Kohsuke, Kudo %D 2023 %\ 01/01/2023 %V 11 %N 1 %P 93-96 %! Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome %K opsoclonus-myoclonus syndrome %K Neuroblastoma %K Brain Perfusion SPECT %R 10.22038/aojnmb.2022.65833.1459 %X A 2-year-old girl started to wobble without any specific triggers, so the patient was admitted to our hospital's pediatric department. The entire cerebellum showed severe atrophy on MRI and much lower uptake than that in the cerebral cortex on perfusion SPECT. The diagnosis of opsoclonus-myoclonus syndrome (OMS) was suspected. MRI visualized a small mass behind the inferior vena cava. Although its uptake on I-123 MIBG scintigraphy was inconclusive, the mass was surgically removed, and the diagnosis of neuroblastoma was pathologically confirmed. OMS is one of the paraneoplastic neurological syndromes with cerebellar ataxia, myoclonus of the trunk and extremities, and opsoclonus as its main symptoms. Approximately 50% of children cases with OMS are associated with neuroblastoma. The prognosis for neuroblastoma itself with OMS is relatively good, but the neurological prognosis is very poor. If there is decreased blood flow in the cerebellum of an infant, it may be necessary to search for neuroblastoma. %U https://aojnmb.mums.ac.ir/article_20938_eaf9b24921cd88510ca08caa6dfe6ae8.pdf