TY - JOUR
ID - 11610
TI - Effect of Beta Particles Spectrum on Absorbed Fraction in Internal Radiotherapy
JO - Asia Oceania Journal of Nuclear Medicine and Biology
JA - AOJNMB
LA - en
SN - 2322-5718
AU - Ghorbani, Mahdi
AU - Hashempour, Marjan
AU - Amato, Ernesto
AU - Knaup, Courtney
AD - Biomedical Engineering and Medical Physics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AD - Physics Group, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran,
AD - Department of Biomedical and Dental Sciences and of Morpho functional Imaging, University of Messina, Messina
AD - Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, USA, Courtney
Y1 - 2019
PY - 2019
VL - 7
IS - 1
SP - 71
EP - 83
KW - Beta emitters
KW - absorbed fraction
KW - analytical function
KW - Monte Carlo Simulation
KW - internal radiotherapy
DO - 10.22038/aojnmb.2018.11610
N2 - Objective(s): The purpose of this research is to study the effect of beta spectrum on absorbed fraction ( ) and to find suitable analytical functions for beta spectrum absorbed fractions in spherical and ellipsoidal volumes with a uniform distribution for several radionuclides that are commonly used in nuclear medicine.Methods: In order to obtain the beta particle absorbed fraction, Monte Carlo simulations were performed by using the MCNPX code. The validation of the simulations was performed by calculating the absorbed fractions in spheres and comparing the results with the data published by other investigators. The absorbed fractions were calculated and compared by using an actual beta energy spectrum with those obtained through the mean beta energy of 14C, 199Au, 177Lu, 131I, 90Sr, 153Sm, 186Re, 32P, 90Y, 38Cl and 88Rb radionuclides.Results: The maximum difference between the absorbed fractions for beta particles accounting for the whole beta spectrum of all the considered nuclides was 29.62% with respect to the mean beta energy case. Suitable analytical relationships were found between the absorbed fraction and the generalized radius, and the dependence of the fitting parameters from beta spectrum energy was discussed and fitted by appropriate parametric functions.Conclusion: The results allowed the calculation of the absorbed fractions from the above stated beta sources uniformly distributed in spherical and ellipsoidal volumes of any ellipticity and volume, in a wide range of practical volumes that are not only used for internal dosimetry in nuclear medicine applications, but also in radiological protection estimates ofdoses from internal contamination.
UR - https://aojnmb.mums.ac.ir/article_11610.html
L1 - https://aojnmb.mums.ac.ir/article_11610_46b41c23f67de9809a871a6eb6a900c0.pdf
ER -