TY - JOUR ID - 21795 TI - Thyroid Receptor Antibody and the Development of Graves’ Orbitopathy: Clinical Experience of using Radioiodine Ablation in the Management of Graves’ Orbitopathy in post-iodine ablation hypothyroid patient JO - Asia Oceania Journal of Nuclear Medicine and Biology JA - AOJNMB LA - en SN - 2322-5718 AU - Christina, Edelyn AU - Budiawan, Hendra AU - Indrawati, Hapsari AU - Soeriadi, Erwin Affandi AU - Nugrahadi, Trias AU - Kartamihardja, A Hussein AD - Department of Nuclear Medicine, Padjadjaran University, Bandung, Indonesia AD - Department of Nuclear Medicine, Mochtar Riady Comprehensive Cancer Center Siloam Hospital, Jakarta, Indonesia AD - Department of Nuclear Medicine, Hasan Sadikin Central Hospital, Bandung, Indonesia Y1 - 2023 PY - 2023 VL - 11 IS - 2 SP - 185 EP - 190 KW - Graves’ orbitopathy KW - Graves’ ophthalmopathy KW - radioactive iodine KW - thyroid receptor antibody DO - 10.22038/aojnmb.2023.68546.1478 N2 - Graves’ disease (GD) is the commonest cause of hyperthyroidism, accounted for 70-80% in iodine sufficient countries and up to 50% in iodine deficient countries. Combination of genetic predisposition and environmental factors influences the development of GD. Graves’ orbitopathy (GO) represents the most common extra-thyroidal manifestation of GD with substantial impact on morbidity and quality of life. Expression of thyroid stimulating hormone receptor (TSHR) mRNA and protein in orbital tissues infiltrated by the activated lymphocytes produced by thyroid cells (Thyroid Receptor Antibody) results in the secretion of inflammatory cytokines that leads to the development of histological and clinical characteristics of GO. A subdivision of TRAb, thyroid stimulating antibody (TSAb), was found to have a close relationship with the activity and severity of GO, and suggested to be considered as a direct parameter of GO. Here, we present a 75-year-old female with a history of GD that has successfully been treated with radioiodine treatment, who developed GO 13 months after therapy while being hypothyroid with high TRAb level. The patient was given a second dose of radioiodine ablation to maintain GO with successful result. UR - https://aojnmb.mums.ac.ir/article_21795.html L1 - https://aojnmb.mums.ac.ir/article_21795_6eb98a1e31b01c99303d8939afe9917e.pdf ER -