TY - JOUR ID - 3144 TI - C-11 Choline and FDG PET/CT Imaging of Primary Cholangiocarcinoma – a Comparative Analysis JO - Asia Oceania Journal of Nuclear Medicine and Biology JA - AOJNMB LA - en SN - 2322-5718 AU - Chotipanich, Chanisa AU - Promteangtrong, Chetsadaporn AU - Kunawudhi, Anchisa AU - Chanwat, Rawisak AU - Sricharunrat, Thaniya AU - Suratako, Savitree AU - Wongsa, Paramest AD - National Cyclotron and PET Centre, Chulabhorn Hospital, Thailand AD - Surgery Department, Chulabhorn Hospital, Thailand AD - Pathology Department, Chulabhorn Hospital, Thailand Y1 - 2015 PY - 2015 VL - 3 IS - 1 SP - 18 EP - 25 KW - Cholangiocarcinoma KW - FDG KW - Choline KW - PET/CT KW - Radiotracer DO - 10.7508/aojnmb.2015.01.004 N2 - Objective(s): This study aimed to compare the diagnostic values of 11C-choline and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with cholangiocarcinoma (CCA). Methods: This prospective study was conducted on 10 patients (6 males and 4 females), aged 42-69 years, suspected of having CCA based on CT or magnetic resonance imaging (MRI) results. 11C-choline and 18F-FDG PET/CT studies were performed in all patients over 1 week. PET/CT results were visually analyzed by 2 independent nuclear medicine physicians and quantitatively by calculating the tumor-to-background ratio (T/B). Results: No 11C-choline PET/CT uptake was observed in primary extrahepatic or intrahepatic CCA cases. Intense 18F-FDG avidity was detected in the tumors of 8 patients (%80). Two patients, who were 18F-FDG negative, had primary extrahepatic CCA. Ki-67 measurements were positive in all patients (range; 14.2%-39.9%). The average T/B values of 11C-choline and 18F-FDG were 0.4±0.2 and 2.0±1.0 in all cases of primary CCA, respectively; these values were significantly lower for 11C-choline (P<0.005). Both FDG and 11C-choline PET/CT detected metastatic CCA foci in all 8 patients (two patients had no metastases). Conclusion: As the results suggested, primary CCA lesions showed a poor avidity for 11C-choline, whereas 18F-FDG PET/CT was of value for the detection of most primary CCA cases. In contrast to primary lesions, metastatic CCA lesions showed 11C-choline avidity. UR - https://aojnmb.mums.ac.ir/article_3144.html L1 - https://aojnmb.mums.ac.ir/article_3144_7d6ae24bc07532fc79f93395bc91ec49.pdf ER -