TY - JOUR ID - 5341 TI - Background-Based Delineation of Internal Tumor Volumes on Static Positron Emission Tomography in a Phantom Study JO - Asia Oceania Journal of Nuclear Medicine and Biology JA - AOJNMB LA - en SN - 2322-5718 AU - chen, yangchun AU - Chen, Xiangrong AU - Liu, Ji-an AU - Li, Fanyong AD - Department of Nuclear Medicine, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China AD - Department of Radiology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China AD - Guangdong Provincial Key Laboratory of Micro-nano Manufacturing Technology and Equipment, Guangdong University of Technology, Guangzhou, China AD - The PET-CT Center, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Y1 - 2016 PY - 2016 VL - 4 IS - 1 SP - 38 EP - 44 KW - Gross tumor volume KW - internal tumor volume KW - Positron Emission Tomography KW - standardized uptake value DO - 10.7508/aojnmb.2016.04.006 N2 - Objective(s): Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. Methods: Three hollow models were filled with 55.0 kBq/mL fluorine18- fluorodeoxyglucose (18F-FDG) to represent tumors. The models were fixed to a barrel filled with 5.9 kBq/mL 18F-FDG to characterize normal lung tissues as a phantom. The PET/CT images of the phantom were acquired at rest. Then, the barrel was moved periodically to simulate breathing while acquiring PET/CT data. Volume recovery coefficient (VRC) was applied to evaluate the accuracy of ITVs. For statistical analysis, paired t-test and analysis of variance were applied. Results: The VRCs ranged from 0.74 to 0.98 and significantly varied among gross tumor volumes for delineating ITV (P<0.01). In two-dimensional PET scans, the motion distance did not affect VRC (P>0.05), whereas VRC decreased with increasing distance in three-dimensional PET scans (P<0.05). Conclusion: The threshold value (x+3×SD) had the potential to delineate the ITV of cancerous tissues, surrounded by lung tissues, particularly in two-dimensional PET images.      UR - https://aojnmb.mums.ac.ir/article_5341.html L1 - https://aojnmb.mums.ac.ir/article_5341_82de523e76b190f9e1e61d6daf132d8d.pdf ER -