TY - JOUR ID - 8844 TI - 99mTc-TRODAT-1 SPECT Imaging in Early and Late Onset Parkinson’s Disease JO - Asia Oceania Journal of Nuclear Medicine and Biology JA - AOJNMB LA - en SN - 2322-5718 AU - Sasannezhad, Payam AU - Ghabeli Juibari, Ali AU - Sadri, Kayvan AU - Dabbagh Kakhki, Vahidreza AU - Sadeghi, Ramin AU - Sabour, Mahsa AU - Alizadeh, Hesam AD - Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran AD - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2017 PY - 2017 VL - 5 IS - 2 SP - 119 EP - 125 KW - Tc-99m-TRODAT-1 KW - Parkinson's disease KW - Early onset KW - Late onset KW - dopamine transporter DO - 10.22038/aojnmb.2017.8844 N2 - Objective(s): 99mTc-TRODAT-1, which binds to the dopamine transporter, could be used to image the dopaminergic system in diagnosis of Parkinson’s disease (PD). PD can be classified into two groups: late onset Parkinson’s disease (LOPD) and early onset Parkinson’s disease (EOPD). In this study we tried to determine the TRODAT SPECT findings in EOPD as compared to LOPD.Methods: Fifteen patients were studied. The diagnosis of PD was defined by clinical criteria based on UK Parkinson’s Disease Society Brain Bank criteria. Six patients whose age at onset of PD were younger than 50 were defined as patients with EOPD and 9 patients with older than 50 years were defined as patients with LOPD. All patients underwent 99mTc-TRODAT Brain SPECT.Results: There was a significant decrease of striatal 99mTc-TRODAT-1 (TRODAT) binding in PD patients in both EOPD and LOPD. No significant difference was noticed between EOPD and LOPD in disease stage and symptoms. In visual analysis, 20 (66.67%) caudate nucleuses had decreased tracer uptake while all 30 (100%) putamens had decreased or absent tracer uptake. No significant difference between EOPD and LOPD was noticed in visual analysis. Striatum, Caudate and Putamen uptake ratio to background were calculated. No significant difference was noticed between EOPD and LOPD in these ratios. However there was significant difference in visual analysis (tracer uptake) as well as in uptake ratio between putamen and caudate nucleuses in both groups (P=0.001). On the other word, we found more diminished uptake in putamen as compared the caudate. Frequency and severity of putamen involvement were much more than caudate.Conclusion: 99mTc-TRODAT-1 SPECT imaging showed lower presynaptical dopami-nergical terminals density in both EOPD and LOPD. There was no difference between EOPD and LOPD in TRODAT uptake. Putamen showed more involvement and more diminished TRODAT uptake.  UR - https://aojnmb.mums.ac.ir/article_8844.html L1 - https://aojnmb.mums.ac.ir/article_8844_5fd82ad7eb27b7df0f5e697fab12cca1.pdf ER -