<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Asia Oceania Journal of Nuclear Medicine and Biology</title>
			<title_fa></title_fa>
			<short_title>AOJNMB</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://aojnmb.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-5718</journal_id_issn>
			<journal_id_issn_online>2322-5726</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2024</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>12</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>On the Optimization of the Protocol for Automated Radiosyntheses of [68Ga]Ga-Pentixafor, [68Ga]Ga-FAPI-4 and [68Ga]Ga-DOTATATE in a Modular-Lab Standard</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: The present work describes the automated radiochemical syntheses of different PET tracers like [68Ga]Ga-Pentixafor, [68Ga]Ga-FAPI-4 and [68Ga]Ga-DOTATATE using optimized single protocol in the non-cassette based Eckert &amp; Ziegler (EZ) Modular Lab (fixed tubing system) without any modification in the inbuilt human machine interface (HMI) software. Recently, PET agents viz. [68Ga]Ga-Pentixafor and [68Ga]Ga-FAPI-4 are gaining prominence for the diagnosis of overexpressed Chemokine Receptor-4 (CXCR4) and Fibroblast Activation Protein (FAP) receptor, respectively, in the microenvironment of numerous cancer types. The promising results observed with the clinical usage of [68Ga]Ga-DOTATATE produced using the automated protocol, provided impetus for the clinical translation of [68Ga]Ga-Pentixafor and [68Ga]Ga-FAPI-4 using the in-house developed automated radiolabeling protocol.Methods: Herein we report a single radiolabeling protocol for the automated preparation of [68Ga]Ga-Pentixafor and [68Ga]Ga-FAPI-4 in the non-cassette based EZ Modular-Lab Standard radiochemistry module, without any changes in schematic, graphical user interface (GUI) software and time list, from that used for routine production of [68Ga]Ga-DOTATATE in our centre, since 2015. Physico-chemical quality control and in-vitro stability analyses were carried out using radio-TLC and radio-HPLC.Results: The automated protocol yielded reliable and consistent non-decay corrected (ndc) radiochemical yield (RCY) of (84.4±0.9)% and (85.5±1.4)% respectively, for [68Ga]Ga-Pentixafor and [68Ga]Ga-FAPI-4, with RCP&gt; 98%, which are comparable to the RCY of (84.4±1.2)% and RCP (99.1±0.3)% for [68Ga]Ga-DOTATATE. The biological quality control studies confirmed the formulations to be of ready-to-use pharmaceutical grade.Conclusion: The consistent and reliable RCY and RCP of multiple 68Ga-labeled PET tracers by single optimized automated radiochemistry protocol exhibits the versatility of the EZ Modular Lab.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>[68Ga]Ga-Pentixafor, [68Ga]Ga-FAPI-4, [68Ga]Ga-DOTATATE, Modular-Lab Standard, PET/CT</keyword>
				<start_page>149</start_page>
				<end_page>160</end_page>
				<web_url>https://aojnmb.mums.ac.ir/article_23839.html</web_url>
			<author_list><author>
				<first_name>Sreeja</first_name>
				<middle_name>Raj</middle_name>
				<last_name>Menon</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sreeja.rm@gmail.com</email>
				<code>104379</code>
				<coreauthor>No</coreauthor>
				<affiliation>Health Physics Division, Bhabha Atomic Research Centre, Mumbai, India|Homi Bhabha National Institute, Mumbai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Arpit</first_name>
				<middle_name></middle_name>
				<last_name>Mitra</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>arpitmitra@gmail.com</email>
				<code>104380</code>
				<coreauthor>No</coreauthor>
				<affiliation>Radiopharmaceutical Laboratory, Board of Radiation and Isotope Technology, Navi Mumbai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sudeep</first_name>
				<middle_name></middle_name>
				<last_name>Sahu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sudeep.sahu4@gmail.com</email>
				<code>104381</code>
				<coreauthor>No</coreauthor>
				<affiliation>Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sangita</first_name>
				<middle_name></middle_name>
				<last_name>Lad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shalmali676@gmail.com</email>
				<code>104382</code>
				<coreauthor>No</coreauthor>
				<affiliation>Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Avik</first_name>
				<middle_name></middle_name>
				<last_name>Chakraborty</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>avikbarc@gmail.com</email>
				<code>104383</code>
				<coreauthor>No</coreauthor>
				<affiliation>Homi Bhabha National Institute, Mumbai, India|Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mukti</first_name>
				<middle_name>Kanta</middle_name>
				<last_name>Ray</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>muktiray@gmail.com</email>
				<code>104384</code>
				<coreauthor>No</coreauthor>
				<affiliation>Homi Bhabha National Institute, Mumbai, India|Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sharmila</first_name>
				<middle_name></middle_name>
				<last_name>Banerjee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sharmila@barc.gov.in</email>
				<code>104385</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Homi Bhabha National Institute, Mumbai, India|Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>