<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Asia Oceania Journal of Nuclear Medicine and Biology</title>
			<title_fa></title_fa>
			<short_title>AOJNMB</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://aojnmb.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-5718</journal_id_issn>
			<journal_id_issn_online>2322-5726</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>1</month>
				<day>1</day>
			</pubdate>
			<volume>13</volume>
			<number>1</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>[18F]FDG PET/CT volumetric biomarkers for non-invasive prediction of HER2 expression in breast cancer patients</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): to investigate the capability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]-FDG PET/CT) derived volumetric parameters to predict human epidermal growth factor receptor 2 (HER2) status in breast cancer patients.Methods: retrospective study enrolled 47 female patients with breast cancer. All patients had pretreatment [18F]-FDG PET/CT. Clinical data, pathology report and HER2 status were retrieved from medical records. In an attempt to assess the predictive value of the PET-derived metabolic parameters, Receiver operating characteristic (ROC) curve was constructed with area under curve analysis performed to detect best cutoff value of significant parameters for detection of HER2 positive.Results: No statistically significant difference was noted among both groups (HER2 positive and negative) in respect to age, menopausal status, histology, grade, T-stage, N-stage, or antigen Kiel 67 (Ki-67) index. ROC curve successfully marked cutoff point ≥42.35 for total lesion glycolysis (TLG) and ³12.75 for metabolic tumor value (MTV) that are capable to discriminate positive versus negative HER2 expression in breast cancer patients with area under curve (AUC) 0.728 and 0.723 and P-values 0.002 and 0.004 respectively. Such cutoff point was not deduced for standard uptake value (SUV) max. Primary tumor TLG cutoff correlated well with age where 77.8% of patients with TLG  ³42.35 were older than 45 years old compared to 22.2% of them who were younger than 45 years, P-value=0.047. Also 70.3% of patients with TLG exceeds  ³42.35 had T3 and 4 primary tumors while 65% of those with TLG &lt;42.35 their primary tumors were T1 and 2, P-value=0.03. As regards Primary tumor MTV cutoff point, significant correlations were noted in respect to T-stage where 78.2% of the patients with primary tumor MTV ³12.75 were T3 and 4, compared to 66.6% of those with primary tumor MTV &lt;12.75 were T1 and 2, P-value=0.011.Conclusion: PET-derived volumetrics may serve as non-invasive predictors of biological processes represented here as HER2 expression in breast cancer patients.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>PET/CT, HER2, Breast Cancer</keyword>
				<start_page>10</start_page>
				<end_page>20</end_page>
				<web_url>https://aojnmb.mums.ac.ir/article_25067.html</web_url>
			<author_list><author>
				<first_name>Mai</first_name>
				<middle_name>Amr</middle_name>
				<last_name>ELahmadawy</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mai.elahmadawy@nci.cu.edu.eg</email>
				<code>109931</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Nuclear Medicine Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Heba</first_name>
				<middle_name></middle_name>
				<last_name>Abdelhameed</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>heba.abdelhameed187@gmail.com</email>
				<code>109932</code>
				<coreauthor>No</coreauthor>
				<affiliation>Clinical oncology and nuclear medicine department, Zagazig University, Zagazig Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Dina</first_name>
				<middle_name>Hosny</middle_name>
				<last_name>Gamal El-din</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dina.hosny@kasralainy.edu.eg</email>
				<code>109933</code>
				<coreauthor>No</coreauthor>
				<affiliation>Radiology department , Kasr Al Aini medical school, Cairo University, Cairo, Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahitab</first_name>
				<middle_name></middle_name>
				<last_name>Eltohamy</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mahitabaltohami@yahoo.com</email>
				<code>109934</code>
				<coreauthor>No</coreauthor>
				<affiliation>Pathology department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Adel</first_name>
				<middle_name>Mohamed Ismail</middle_name>
				<last_name>Hassan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yassinadel2014@gmail.com</email>
				<code>109935</code>
				<coreauthor>No</coreauthor>
				<affiliation>Surgical Oncology department, Ismailia teaching oncology hospital, Ismailia, Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Salwa</first_name>
				<middle_name></middle_name>
				<last_name>Abd El-Gaid</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rwan2004@gmail.com</email>
				<code>109936</code>
				<coreauthor>No</coreauthor>
				<affiliation>Nuclear Medicine Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>