Feasibility of shortened scan acquisition time with IQ-SPECT technology using SMARTZOOM(TM) collimator in myocardial perfusion imaging

Document Type : Original Article

Authors

Department of Nuclear Medicine, Apollo Hospitals, Chennai, India

10.22038/aojnmb.2025.78149.1551

Abstract

Objective(s): IQ-SPECT technology uses cardiac-specific SMARTZOOM(TM) collimator that can reduce the time required to acquire myocardial perfusion images to half (14 seconds/view) of a standard SPECT procedure. This study aimed to further shorten the scan acquisition time (7 seconds/view) using the SMARTZOOM(TM) collimator without compromising the image quality.
Methods: This prospective observational study involved 50 patients (39 men and 11 women) who underwent myocardial perfusion studies using the SMARTZOOM(TM) collimator. The scans were acquired in 7 seconds/view (Group A) and 14 seconds/view (Group B). Attenuation-corrected (AC), non-attenuation-corrected (NAC), and polar maps were generated for both groups using the QGS/QPS software. The groups were qualitatively and quantitatively compared in terms of image quality, relative uptake score, summed scores, total perfusion deficit, and left ventricular ejection fraction (LVEF). 
Results: The image quality of both groups was comparable in the AC studies, whereas Group B was superior to Group A in the NAC studies. All images exhibited an image quality score of ≥3, which suggested adequate image quality. The mean LVEF values were 62.16 and 64.34 in Groups A and B, respectively (p-value 0.326). A strong positive correlation was observed between the two datasets (Pearson’s r=0.59). The mean summed score in the AC images was 7.5 in both groups (p-value 0.49), and in the NAC images, the scores were 7.68 in Group A and 7.46 in Group B (p-value 0.46). The mean total perfusion deficits calculated using the 17-segment models were 11% and 16% in Group A and Group B, respectively, for the AC images (p-value 0.143) and 11.2% and 16.5% in Group A and Group B, respectively, for the NAC images (p-value 0.135). Significant differences were not noted in the calculation of the relative uptake score in segments 1– 17 for the AC and NAC images in Groups A and B.
Conclusion: The findings from this study indicate that further shortening of the scan acquisition time to 7 seconds/view is possible in myocardial perfusion imaging using the SMARTZOOM(TM) collimator without compromising the scan quality and the results, thus improving patient comfort.  

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  1. Erwin WD, Jessop AC, Mar MV, Macapinlac HA, Mawlawi OR. Qualitative and quantitative comparison of gated blood pool single photon emission computed tomography using low-energy high-resolution and SMARTZOOM(TM) collimation. Nuclear medicine communications. 2017; 38(1): 35-43.
  2. Du Y, Bhattacharya M, Frey EC. Simultaneous Tc-99m/I-123 dual-radionuclide myocardial perfusion/ innervation imaging using Siemens IQ-SPECT with SMARTZOOM(TM) collimator. Physics in Medicine & Biology. 2014; 59(11): 2813.
  3. Horiguchi Y, Ueda T, Shiomori T, Kanna M, Matsushita H, Kawaminami T, Sudo Y, Kikuchi S, Sasaki R, Hoshimiya J, Morita Y. Validation of a short-scan-time imaging protocol for thallium-201 myocardial SPECT with a multifocal collimator. Annals of nuclear medicine. 2014; 28: 707-15.
  4. Pirich C, Keinrath P, Barth G, Rendl G, Rettenbacher L, Rodrigues M. Diagnostic accuracy and functional parameters of myocardial perfusion scintigraphy using accelerated cardiac acquisition with IQ SPECT technique in comparison to conventional imaging. The Quarterly Journal of Nuclear Medicine and Molecular Imaging. 2017; 61(1): 102-107.
  5. Lyon MC, Foster C, Ding X, Dorbala S, Spence D, Bhattacharya M, et al. Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation. Journal of Nuclear Cardiology. 2016; 23(4): 657-67.
  6. Caobelli F, Kaiser SR, Thackeray JT, Bengel FM, Chieregato M, Soffientini A, et al. The importance of a correct positioning of the heart using IQ-SPECT system with multifocal collimators in myocardial perfusion imaging: a phantom study. Journal of Nuclear Cardiology. 2015; 22(1): 57-65.
  7. Einstein AJ, Blankstein R, Andrews H, Fish M, Padgett R, Hayes SW, et al. Comparison of image quality, myocardial perfusion, and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: the MILLISIEVERT study. Journal of Nuclear Medicine. 2014; 55(9): 1430-7.
  8. Hippeläinen E, Mäkelä T, Kaasalainen T, Kaleva E. Ejection fraction in myocardial perfusion imaging assessed with a dynamic phantom: comparison between IQ-SPECT and LEHR. EJNMMI physics. 2017; 4(1):1-4.
  9. Abbott BG, Case JA, Dorbala S, Einstein AJ, Galt JR, Pagnanelli R, et al. Contemporary cardiac SPECT imaging—innovations and best practices: an information statement from the American society of nuclear Circulation: Cardiovascular Imaging. 2018; 11(9): e000020.
  10. Caobelli F, Thackeray JT, Soffientini A, Bengel FM, Pizzocaro C, Guerra UP. Feasibility of one-eighth time gated myocardial perfusion SPECT functional imaging using IQ-SPECT. European journal of nuclear medicine and molecular imaging. 2015; 42: 1920-8.
  11. Doğan C, Çınaral F, Karagöz A, Bayram Z, Önal SÇ, Candan Ö, et al. Comparison of automated quantification and semi quantitative visual analysis findings of IQ SPECT MPI with conventional coronary angiography in patients with stable angina. Turk Kardiyol Dern Ars. 2019; 47(5): 357-64.
  12. Joergensen T, Hansson SH. Evaluation of the left ventricular ejection fraction with gated IQ-SPECT myocardial perfusion imaging. Journal of Nuclear Medicine Technology. 2015; 43(3): 193-200.
  13. Leva L, Matheoud R, Sacchetti G, Carriero A, Brambilla M. Agreement between left ventricular ejection fraction assessed in patients with gated IQ-SPECT and conventional imaging. Journal of Nuclear Cardiology. 2020; 27(5): 1714-24.
  14. Caobelli F, Kaiser SR, Thackeray JT, Bengel FM, Chieregato M, Soffientini A, et al. IQ SPECT allows a significant reduction in administered dose and acquisition time for myocardial perfusion imaging: evidence from a phantom study. Journal of Nuclear Medicine. 2014; 55(12): 2064-70.