A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques

Document Type: Short communication

Authors

1 Department of Radiology, Perelman School of Medicine, University of Pennsylvania, PA, United States

2 Department of Medicine, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA, United States

Abstract

Objective(s): Functional imaging presents a non-invasive process that may capture the hyper-metabolic nature of red bone marrow in myeloproliferative neoplasms, such as polycythemia vera (PV).
Methods: This study analyzed the FDG-PET/CT scans (n=12) of six patients diagnosed with PV and six age-sex matched controls using a quantitative global analysis methodology.
Results: All PV patients had elevated activities in the bone marrow of each skeletal structure as compared to matched controls with respect to mean standardized uptake value (femoral neck p=0.01, lumbar spine p=0.02, pelvis p=0.002, sternum p=0.04). Notable variations in splenic uptake were observed among the treated and untreated PV patients.  
Conclusion: Our study exemplifies the potential utility of PET in reflecting hyperactive bone marrow activity related to PV. Future studies may further substantiate and elaborate on the use of PET-derived metabolic data in PV.

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