A Unique Coincidence: Concurrent Oncocytic Thyroid Carcinoma and Tenosynovial Giant Cell Tumor: A Case Report.

Articles in Press

Document Type : Case report

Authors

1 Nuclear Medicine Department, King Hussein Cancer Center

2 Diagnostic Radiology Department, King Hussein Cancer Center

3 Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan

4 King Hussein Cancer Center

10.22038/aojnmb.2026.87172.1625

Abstract

Oncocytic thyroid carcinoma (OTC) and tenosynovial giant cell tumor (TGCT) are rare neoplasms with distinct clinical and pathological presentations. This case report presents an unusual occurrence of these two tumors in a single patient.

A 45-year-old male with a history of recurrent OTC developed a rapidly growing soft tissue mass in his left ankle. Initial imaging studies, including 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG) show intense hypermetabolic bilateral thyroid bed focal lesions as well as hypermetabolic infiltrative soft tissue lesions involving left ankle and ventral surface of the foot with multiple lytic bone lesions and cortical distribution of the calcaneal and few tarsal bones. However, subsequent biopsy confirmed a diagnosis of TGCT.

This case highlights the value of FDG PET/CT in the diagnosis of both OTC and TGCT. FDG PET/CT is a powerful imaging modality that can detect metabolically active lesions, such as these two tumors. Its high sensitivity allows for early detection and accurate disease staging.

FDG PET/CT has limitations, as it may lack specificity in distinguishing benign from malignant lesions. Thus, combining clinical assessment, histopathology, and additional imaging is vital for accurate diagnosis and patient care.

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Asia Oceania Journal of Nuclear Medicine and Biology

Articles in Press, Accepted Manuscript
Available Online from 21 February 2026

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