The Early Years of Nuclear Medicine: A Retelling

Document Type : History and perspective

Authors

1 Department of Nuclear Medicine, Philippine Heart Center, Philippine General Hospital, University of the Philippines,Philippines

2 Curator, Dr. Saul Hertz Archives, United States of America

Abstract

Nuclear medicine history has its share of captivating personalities, controversial claims, and forgotten pioneers. Publications and documents that came out relatively recently, provide us with new perspectives on its history. Primary sourced material might contradict some of the long-held beliefs of the reader who only has a casual familiarity with the events, including basics such as who discovered radioactivity.
Because of the nature of the specialty, the importance of the contributions of colleagues in related fields, like physics and chemistry, cannot be overstated. Many of the important discoveries were marked by serendipity, but the pioneers must be given credit for having the necessary insights to interpret the new phenomena correctly, sometimes turning perceived “failure” into novel scientific principles. In addition, most of our pioneers had to deal with inadequate facilities and funding, religious and racial discrimination, and even misogynism.
The early history of nuclear medicine is presented in this article as a series of its most interesting anecdotes, from the early work on radioactivity, to the conception of the tracer principle, until the development of radioactive iodine therapy.

Keywords

References

1. Department of Radiology, University of Washington. Featured History: Wilhelm Roentgen. https://rad.washington.edu/ blog/ featured history-wilhelm-rontgen. Accessed 2 January 2021.
2. Chodos A, Ouellette J. November 8, 1895: Roentgen’s Discovery of X-rays. American Physical Society APS News. Nov 2001; 10(10):2.
3. Habashi F. Niepce de Saint-Victor and the Discovery of Radioactivity. Bull Hist Chem 2001; 26:104-105 .
4. Chodos A, Ouellette J, Tretkoff E. March 1, 1896: Henri Becquerel Discovers Radio-
activity. American Physical Society APS News. Mar 2008; 17(3):2.
5. Strauss HW, Zaret B, Pieri G, Lahiri A. History corner: Antoine Henri Becquerel. J Nucl Cardiol 2017; 24:1515-6.
6. Niepce de Saint Victor CFA. On a new action of light. CR Acad Sci 1857; 45: 811-5.
7. Meyer M, Gonthier E. Is there still controversy surrounding the discovery of so-called radioactive phenomena? http://www.tribunes. com/tribune/ art97
/meyer.htm. Accessed 10 July 2017.
8. Becquerel E. La lumière: Ses causes et ses effets, (Light: Its causes and effects) vol. 2. 1st ed. Paris: F. Didot; 1868.
9. Naomi Pasachoff. Marie Curie and the Science of Radioactivity. 1st ed. Oxford: Oxford University Press; 1996.
10. Redniss L. Radioactive: Marie & Pierre Curie: A Tale of Love and Fallout. 1sted. New York: It Books; 2010.
11. Wilkie T. The Secret Sex Life of Marie Curie. The Independent. 12 June 1995. https: //www.independent.co.uk/news/science/ secret-sex-life-marie-curie-1586244.html. Accessed 10 September 2017.
12. Nobel Media AB. Pierre Curie Biographical. https://www.nobelprize.org/ prizes/ physics/ 1903/Pierre curie/ biographical/. Accessed 15 September 2019.
13. Frame P. How the Curie Came to Be. Health Physics Society's Newsletter. 1996. https: //www.orau.org/ptp/articles stories/ the curie.htm. Accessed 2 January 2021.
14.Krulwich R. Don’t Come To Stockholm! Madame Curie’s Nobel Scandal. https: //www.npr.org/sections/krulwich/2010/12/14/132031977/dont-come -to-stock holm- madame-curie-s-nobel-scandal. Accessed 11 September 2017.
15. Jorgensen TJ. How Marie Curie Brought X-Ray Machines to the Battlefield. Smit-hsonianmag.com. October 11, 2017. Accessed 2 January 2021.
16. Valiunas A. The Marvelous Marie Curie. The New Atlantis, Number 37, Fall 2012, pp. 51-70.
17. Levi H. George de Hevesy. Life and Work. Copenhagen: Rhodos Press; 1985. Pp 147 .
18. Hevesy G, Paneth F. The Solubility of Lead Sulphide and Lead Chromate. Z Anorg Chem 1913; 82:322
19. Myers WG. Georg Charles de Hevesy: The Father of Nuclear Medicine. J Nucl Med 1979; 20(6):590-4.
20. Niels Bohr Archive. Hevesy Anecdotes 2010. http://www.nba-old.nbi.dk/ hevesyanec.html. Accessed 6 January 2021.
21. Niels Bohr Institute. George de Hevesy: The Origin of Nuclear Medicine. 16 February 2010).https://www.nbi.ku.dk/english/ www/george/dehevesy/del1/. Accessed 6 January 2021.
22. Christiansen IA, Hevesy G, Lomholt S. Radiochemical Method of Studying the Circulation of Bismuth in the Body. C. R. Acad. Sci. 1924; 178:1324.
23. Christiansen IA, Hevesy G, Lomholt S. Radiochemical Method of Studying the Circulation of Lead in the Body. C. R. Acad. Sci. 1924; 179:291.
24. Hevesy, G, Hofer, E. Elimination of water from the human body. Nature 1934; 134: 879.
25. Chievitz O, Hevesy G. Radioactive Indicators in the Study of Phosphorus Metabolism in Rats. Nature 1935; 13:754.
26. Hevesy G. A Scientific Career. Perspectives in Biology and Medicine. 1958; 1(4):345-365.
27. Gratzer W. Eurekas and Euphorias. The Oxford Book of Scientific Anecdotes. New York; Oxford University Press: 2002. Pp 220-2.
28. Wikipedia.org. Niels Bohr. https://en. wikipedia.org/wiki/Niels_Bohr. Accessed 6 January 2021.
29. Bonilis L. George de Hevesy. Lindau Nobel Laureate Meetings. https://www. mediathe-que.lindau-nobel.org/research-profile/laure ate-de-hevesy# page=all. Accessed 6 January 2021.
30. Nobel Media AB. A unique gold medal. https://www.nobelprize.org/prizes/about/the-nobel-medals-and-the-medal-for-the-prize-in-economic-sciences/. Accessed 6 January 2021.
31. Wikipedia.org. Nuclear Medicine. https://en. wikipedia.org/wiki/ Nuclear medicine. Accessed 6 January 2021.
32. Distinguished Nuclear Pioneer, John Hundale Lawrence. J Nucl Med 1970; 11:292-293.
33. Berkley Lab. From Radioisotopes to Medical Imaging, History of Nuclear Medicine Written at Berkeley. https:// www. lbl. gov/ Science- Articles/ Archive/nuclear-med -history.html. Accessed 8 January 2021.
34. Frame P. Tales from the Atomic Age. Four Tales of George de Hevesy. https://www. orau.org/ptp/articles-stories/hevesy.htm. Accessed 15 May 2017.
35. Hahn, L, Hevesy G. A method of blood volume determination. Acta Physiol. Scandinav., 1940-41:1, 3.
36. Hertz BE, Schuller KR. Saul Hertz, MD (1905-1950): A Pioneer in the Use of Radioactive Iodine. Endocrine Practice 2010; 16(4):713-6.
37. Fahey FH, Grant FD, Thrall JH. Saul Hertz, MD, and the birth of radionuclide therapy. EJNMMI Physics 2017; 4:15-21.
38. Marine D. Quantitative studies on the in vivo absorption of iodine by dogs' thyroid glands. J Biol Chem 1915; 22:547.
39. Ell PJ. The contribution of medical physics to nuclear medicine: a physician's perspective. EJNMMI Physics 2014; 1:3-9.
40. Sawin CT and Becker DV. Radioiodine and the Treatment of Hyperthyroidism: The Early History. Thyroid 1997; 7(2):163-176.
41. Remembering the Early Days of Nuclear Medicine. MGH News, Sep 1987; 46(6):1, 5, 6.
42. Hertz, S., Roberts, A., Evans, R. D., Radioactive iodine as an indicator in thyroid physiology. Proc. Soc. Exp. Biol. and Med., 1938; 38:510-3.
43. Hertz B. Dr. Saul Hertz (1905–1950) Discovers the Medical Uses of Radioactive Iodine: The First Targeted Cancer Therapy. In: Ahmadzadehfar H, editor. Thyroid Cancer: Advances in Diagnosis and Therapy. 2016.
44. Hertz B, A tribute to Dr. Saul Hertz: The discovery of the medical uses of radioiodine. World J Nucl Med. 2019; 18:8-12.
45. Hertz B, Bharadwaj P, Greenspan B, A historic review of the discovery of the medical uses of radioiodine, Pak J Nucl Med 2020;10(1):60–63.
46. Hertz B. Dr. Saul Hertz Discovers the Medical Uses of Radioiodine (RAI). J Radiol Oncol. 2018; 2: 053-054.
47. S Hertz and A Roberts. The Use of Radioactive Iodine Therapy in Hyper-thyroidism. JAMA. 1946; 131(2):81-86.
48. E Chapman and R Evans. The Treatment of Hyperthyroidism with Radioactive Iodine Therapy. JAMA. 1946; 131(2):86-91.
49. Thrall JH, MGH Russell Museum presentation, Saul Hertz: radioiodine and the origins of nuclear medicine." Youtube.com; 2016. Available at www. youtube.com/watch?v=34 Qhm8CeMuc (time index 24:40-25:08). Accessed 27 Novem-ber 2020.
50. Hertz B. Yale Medical School Beaumont Club Presentation 2016, Dr Saul Hertz discovers the medical uses of radioiodine: challenges and legacy. Youtube.com; 2016. Available at www.youtube.com/watch? v=Ssd5K_-rDJQ (time index 46:12- 46:45). Accessed 27 November 2020.
51. Ehrhardt JD, Güleç S. A Review of the History of Radioactive Iodine Theranostics: The Origin of Nuclear Ontology. Mol Imaging Radionucl Ther 2020; 29:88-97.
52. Vincent DG. Hertz to use nuclear fission in cure for cancer. Harvard Crimson May 24, 1949. https://www.thecrimson.com /article /1949/5/24/hertz-to-use-nuclear-fission-in/. Accessed 28 November 2020.
53. Hertz S. Use of Radioactive Iodine in the Diagnosis, Study and Treatment of Diseases of the Thyroid. In: Soskin S, editor. Progress in Clinical Epidemiology. 1st ed. Amsterdam: Elsevier Ltd; 1950. pp 65-78.
54. Lynch J, Radioactive isotope study starts at women’s hospital, Boston Traveler, Sep 30, 1949, p.14.
Asia Oceania Journal of Nuclear Medicine and Biology
Volume 9, Issue 2
July 2021
Pages 207-219

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