Asia Oceania Journal of Nuclear Medicine and Biology

Asia Oceania Journal of Nuclear Medicine and Biology

Antral contractility following Asian-style meal in healthy volunteers: effect of genders, menstruation, smoking status and age.

Document Type : Original Article

Authors
Janyarut Srijumruen 1
Sira Vachatimanont 2
Usanee Techavijit 3
Tawatchai Chaiwatanarat 3
1 Buddhachinaraj Phitsanulok Hospital, Phitsanulok, Thailand
2 Nuclear Medicine Division, Department of Radiology, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thailand
3 Nuclear Medicine Division, Department of Radiology, Chulalongkorn University, Rama IV Rd, Pathumwan, Bangkok, Thailand
10.22038/aojnmb.2021.60453.1423
Abstract
Objective(s):The normal range of the frequency of antral contractions, similar to other gastric motility parameters, are different depending on the population and the test meal. We, therefore, conducted the analysis to establish the normal ranges for the frequency of antral contractions derived from dynamic antral scintigraphy (DAS) following an Asian-styled solid meal in Thai healthy volunteers.
Methods:We retrospectively analyzed the data from the study on normal gastric emptying values. The dynamic scintigraphic images had been obtained in a 45 degree left anterior oblique view during the first 32 minutes following the ingestion of a 267-kcal steamed rice, a technetium-99m-labeled microwaved egg and 100 mL of water. A polynomial normalization model was used to analyze and to calculate the frequency of antral contractions. The data analysis was repeated by the same operator 1 month apart to assess reproducibility.
Results:Data of 18 volunteers (10 males and 8 females) were eligible for analysis. The mean±SD of the frequencies of the antral contractions were 3.06±1.08 cycles/min on the first and 3.04±1.10 cycles/min on the second analysis. Comparison of the two analyses revealed a moderate agreement (ICC=0.632, 95% CI 0.329-0.818) without significant difference (p-value=0.942). No significant effect of gender, menstruation status, smoking or age was demonstrated in this study.
Conclusion:DAS is a non-invasive technique that can measure the frequency of antral contractions. The technique is reproducible and consistent. Future study may be required to assess the effect of gender, menstruation status, smoking and age.
Keywords
Gastrointestinal Motility
Healthy volunteers
Radionuclide imaging
Antral contractility
  1. Keller J, Bassotti G, Clarke J, Dinning P, Fox M, Grover M, et al. Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders. Nat Rev Gastroenterol Hepatol. 2018 May; 15(5):291–308.
  2. Kerlin P. Postprandial antral hypomotility in patients with idiopathic nausea and vomiting. Gut. 1989 Jan; 30(1):54–9.
  3. Misiara GP, Troncon LEA, Hara SH, Secaf M. Dynamic antral scintigraphy following solid and liquid meals in healthy human subjects. Nucl Med Commun. 2007 Jun; 28(6):479–83.
  4. Urbain JL, Vekemans MC, Bouillon R, Van Cauteren J, Bex M, Mayeur SM, et al. Characterization of gastric antral motility disturbances in diabetes using a scintigraphic technique. J Nucl Med. 1993 Apr; 34(4):576–81.
  5. Knight LC, Parkman HP, Brown KL, Miller MA, Trate DM, Maurer AH, et al. Delayed gastric emptying and decreased antral contractility in normal premenopausal women compared with men. Am J Gastroenterol. 1997 Jun; 92(6):968–75.
  6. Vasavid P, Chaiwatanarat T, Pusuwan P, Sritara C, Roysri K, Namwongprom S, et al. Normal Solid Gastric Emptying Values Measured by Scintigraphy Using Asian-style Meal:A Multicenter Study in Healthy Volunteers. J Neurogastroenterol Motil. 2014 Jul 31; 20(3):371–8.
  7. Misiara GP, Troncon LEA, Moraes ER, Secaf M. Comparison between manual and automated techniques for assessment of data from dynamic antral scintigraphy. Ann Nucl Med. 2008 Nov; 22(9):761–7.
  8. Troncon LEA, Herculano JRJ, Savoldelli RD, Moraes ER, Secaf M, Oliveira RB. Relationships between intragastric food maldistribution, disturbances of antral contractility, and symptoms in functional Dig Dis Sci. 2006 Mar; 51(3): 517–26.
  9. Bennink R, Peeters M, Van den Maegdenbergh V, Geypens B, Rutgeerts P, De Roo M, et al. Comparison of total and compartmental gastric emptying and antral motility between healthy men and women. European journal of nuclear medicine. 1998; 25(9):1293–9.
  10. McDONNELL WM, Owyang C. Effects of smoking on interdigestive gastro-intestinal motility. Digestive diseases and sciences. 1995; 40(12):2608–13.
  11. Kadota K, Takeshima F, Inoue K, Takamori K, Yoshioka S, Nakayama S, et al. Effects of smoking cessation on gastric emptying in smokers. Journal of clinical gastroentero-logy. 2010; 44(4): e71–5.
  12. Moore JG, Tweedy C, Christian PE, Datz FL. Effect of age on gastric emptying of liquid-solid meals in man. Digestive diseases and sciences. 1983; 28(4):340–4.
  13. Horowitz M, Maddern GJ, Chatterton BE, Collins PJ, Harding PE, Shearman DJ. Changes in gastric emptying rates with age. Clinical Science. 1984; 67(2):213–8.
  14. Madsen JL, Graff J. Effects of ageing on gastrointestinal motor function. Age and ageing. 2004; 33(2):154–9.
  15. Linke R, Muenzing W, Hahn K, Tatsch K. Evaluation of gastric motility by Fourier analysis of condensed images. European journal of nuclear medicine. 2000; 27(10):1531–7.
  16. Ahmed A, Matre K, Hausken T, Gregersen H, Gilja O. Rome III subgroups of functional dyspepsia exhibit different characteristics of antral contractions measured by strain rate imaging–a pilot study. Ultraschall in der Medizin-European Journal of Ultrasound. 2012; 33(07):E233–40.
  17. Nishizawa T, Masaoka T, Suzuki H. Functional dyspepsia: Pathogenesis, diagnosis, and treatment. Journal of General and Family Medicine. 2016; 17(3):204–10.
  18. Lin HC, Doty JE, Reedy TJ, Meyer JH. Inhibition of gastric emptying by acids depends on pH, titratable acidity, and length of intestine exposed to acid. Am J 1990 Dec; 259(6 Pt 1):G1025-1030.
Asia Oceania Journal of Nuclear Medicine and Biology
Volume 10, Issue 2
July 2022
Pages 84-90