Utility of FDG PET/CT in Sjögren’s Syndrome and associated lymphomas; Lymphomagenesis.

Articles in Press

Document Type : Review article

Authors

1 Department Of Nuclear Medicine All India Institute of Medical Sciences

2 Department of Nuclear Medicine All India Institute of Medical Sciences

3 Assistant Professor,Department of Nuclear Medicine,, Institute of Liver and Biliary Sciences, New Delhi, Delhi, India.

10.22038/aojnmb.2024.76893.1541

Abstract

Sjögren’s syndrome is a chronic systemic autoimmune disease that predisposes to the development of lymphoproliferative disorders of B cell origin. It is associated with the highest risk of lymphoma, particularly non-Hodgkin’s lymphoma, with a prevalence in the range from 2.7% to 9.8% . Primary Sjögren syndrome (SS) is an autoimmune disease affecting exocrine glands, with predisposition to development of lymphoma (lymphomagenesis). Due to its systemic manifestations of the ongoing inflammatory process, it can present with a broad spectrum of signs and symptoms involving any organs beyond the exocrine glands, thereby leading to dryness, pain, and fatigue. We report a case of Sjogren’s syndrome and the role of FDG PET/CT in the primary diagnosis of lymphoma transformation in SS, and we review the literature regarding its utility to assess systemic disease activity and also its role in the SS associated lymphoma with light into the future new PET tracers that can be explored for these indications. Published data suggest promising role of FDG PET/CT in SS associated lymphomas, and demands larger studies for its establishment.

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Asia Oceania Journal of Nuclear Medicine and Biology

Articles in Press, Accepted Manuscript
Available Online from 06 June 2024

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