Improving the image quality of short-time bone SPECT using cadmium-zinc-telluride detectors with SwiftScan

Document Type : Original Article

Authors

1 Department of Radiation Oncology, Saitama Medical University Hospital, Saitama, Japan

2 Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, Hyogo, Japan

3 Department of Nuclear Medicine, International Medical Center, Saitama Medical University, Saitama, Japan

4 Department of Radiology, Saitama Medical University Hospital, Saitama, Japan

5 Department of Nuclear Medicine, Saitama Medical University Hospital, Saitama, Japan

Abstract

Objective(s): This study aimed to evaluate the quality and associated quantitative values of bone single-photon emission computed tomography (SPECT) with and without SwiftScan using a semiconductor camera equipped with a cadmium-zinc-telluride detector.
Methods: Ten patients with bone metastases from prostate cancer who underwent list-mode SPECT/computed tomography using a whole-body semiconductor camera participated in this study. A total of 130 metastatic lesions from 10 patients were analyzed. Standard SPECT images were obtained approximately 3 h later, and the images were constructed with and without SwiftScan.
Results: The visual assessment of 3-dimensional maximum intensity projection images showed that when an image quality score of 4 (good) or better was considered clinically acceptable, it was maintained at 4 or better in the 75% and 50% scans with SwiftScan, whereas only the 75% scan was considered acceptable without SwiftScan. The intraclass correlation coefficient was 0.952 at 5% for the standard time without SwiftScan and 0.990 with SwiftScan. The maximum standardized uptake value (SUVmax) changes were 0 to 9.5 (median 1.1) at 75%, 0.1 to 11.5 (1.65) at 50%, 0 to 15.7 (2.1) at 25%, 0.1 to 33.2 (4.2) at 10%, 0.2 to 8.9 (5.65) at 5% without SwiftScan. On the contrary, the SUVmax changes in absolute value were 0 to 5.4 (median 0.8) at 75%, 0 to 6.5 (1.4) at 50%, 0 to 19.1 (1.7) at 25%, 0 to 24.2 (2.8) at 10%, 0 to 29.9 (2.6) at 5% with SwiftScan. The contrast-to-noise ratios (CNR) were 95.3 at 75%, 88.3 at 50%, 69.2 at 25%, 45.7 at 10%, and 31.6 at 5% without SwiftScan, and 96.9, 91.7, 78.0, 71.6, and 62.0, respectively, using SwiftScan.
Conclusion: With the use of SwiftScan, a 50% reduction in acquisition time was considered acceptable for image quality with reproducible quantitative indices such as SUVmax and CNR.

Keywords

Main Subjects

References

  1. Koulikov V, Lerman H, Kesler M, Sapir EE. 99mTc-MDP bone scintigraphy of the hand: comparing the use of novel cadmium zinc telluride (CZT) and routine NaI(Tl) detectors. EJNMMI Research. 2015; (1): 63.
  2. Rohani MFM, Nawi NM, Shamim SE, Sohaimi WFW, Zainon WMNW, Musarudin M , et al. Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients. Ann Nuc Med. 2020; 34(1): 39–48.
  3. Tabotta F, Jreige M, Schaefer N, Becce F, Prior JO, Lalonde MN. Quantitative bone SPECT/CT: high specificity for identification of prostate cancer bone metastases. BMC Musculoskelet Disord. 2019; 20(1): 619.
  4. Kuji I, Yamane T, Seto A, Yasumizu Y, Shirotake S, Oyama M. Skeletal standardized uptake values obtained by quantitative SPECT/CT as an osteoblastic biomarker for the dis. crimination of active bone metastasis in prostate cancer. Eur J Hybrid Imaging. 2017; 1(1): 2.
  5. Logothetis CJ, Lin SH. Osteoblasts in prostate cancer metastasis to bone. Nat Rev Cancer. 2005; 5(1): 21–8.
  6. Picone V, Makris N, Boutevin F, Roy S, Playe M, Soussan M. Clinical validation of time reduction strategy in continuous step-and-shoot mode during SPECT acquisition. EJNMMI Physics. 2021; 8(1): 10.
  7. Chikamori T, Hida S, Tanaka N, Igarashi Y, Yamashita J, Shiba C, et al. Diagnostic Performance of a Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography System With Low-Dose Technetium-99m as Assessed by Fractional Flow Reserve. Circ J. 2016; 80(5): 1217–24.
  8. Goshen E, Beilin L, Stern E, Kenig T, Goldkorn R, Haim SB. Feasibility study of a novel general purpose CZT-based digital SPECT camera: initial clinical results. EJNMMI Phys, 2018; 5(1): 6.
  9. Yamane T, Kondo A, Takahashi M, Miyazaki Y, Ehara T, Koga K, et al. Ultrafast bone scintigraphy scan for detecting bone metastasis using a CZT whole-body gamma camera. Eur J Nucl Med Mol Imaging. 2019; 46(8): 1672–77.
  10. Yamane T, Takahashi M, Matsusaka Y, Fukushima K, Seto A, Kuji I, et al. Satisfied quantitative value can be acquired by short-time bone SPECT/CT using a whole-body cadmium-zinc-telluride gamma camera. Sci Rep, 2021; 11(1): 24320.
  11. Shiba T, Sekikawa Y, Tateoka S, Shinohara N, Inoue Y, Kuroiwa Y, et al. Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom. EJNMMI Physics. 2022; 9(1): 48.
  12. Shibutani T, Onoguchi M, Naoi Y, Yoneyama H, Konishi T, Tatami R, et al. The usefulness of SwiftScan technology for bone scintigraphy using a novel anthropomorphic Sci Rep, 2021; 11(1):2644.
  13. Isoda T, Baba S, Maruoka Y, Kitamura Y, Tahara K, Sasaki M, et al. Influence of the Different Primary Cancers and Different Types of Bone Metastasis on the Lesion-based Artificial Neural Network Value Calculated by a Computer-aided Diagnostic System, BONENAVI, on Bone Scintigraphy Images. Asia Ocean J Nucl Med Biol. 2017; 5(1). 49–55.
Asia Oceania Journal of Nuclear Medicine and Biology
Volume 13, Issue 1
January 2025
Pages 87-93

Files

Share

How to cite

Statistics