Asia Oceania Journal of Nuclear Medicine and Biology

Asia Oceania Journal of Nuclear Medicine and Biology

Assessment of Ultrasound / Radio-guided Occult Lesion Localization in Non-palpable Breast Lesions

Document Type : Original Article

Authors
Seyed Ali Alamdaran 1
Ayda Sharifi Haddad 2
Navid Daghighi 3
Elaheh Modoodi 3
Ramin Sadeghi 4
Mohammad Naser Forghani 1
Asieh Sadat Fattahi 5
1 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Endoscopic and minimally invasive surgery research center, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/aojnmb.2017.9898
Abstract
Objective(s): Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasoundand radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals. One to ten hours prior to surgery, 0.1-0.2 ml (equivalent to 0.5-1 mCi) of Tc-99m-phytate was injected to the lesion under the guidance of ultrasonography. Then, the lesion was localized using a hand-held gamma probe, and excision of the lesion was performed according to its radioactivity signal. Data analysis was performed using SPSS, version 16. Results: Benign and malignant pathologic results were observed in 77 (81.9%) and 17(18.1%) of the patients, respectively, and the mean volume of the excised tissue was 26.29±27 mm³. 79 patients had a solitary lesion (84%), 55 in the left breast (58.5%) and 39 in superolateral quadrant (41.5%). The mean size of the lesions was 15.7 mm in diameter (ranging from 4 to 34 mm). Additionally, there was a need to secondary surgery in 3 (3.2%) patients and inappropriate localization in 6 (6.4%) patients (subcutaneous or intra-ductal spread of radiodrug). Conclusion: Combination of ultrasound- and radio-guided localization methods for localizing non-palpable breast lesions is a simple and acceptable method for localization with no significant complications. For radio-drug spread and subsequent excessive excised tissue volume, subcutaneous and intra-ductal lesions are not suitable indication for ROLL.
Keywords
Non-palpable breast lesion
localization
Radiopharmaceuticals
ROLL
Ultrasound
Subjects

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Asia Oceania Journal of Nuclear Medicine and Biology
Volume 6, Issue 1
January 2018
Pages 10-14